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St Jude’s Miracle Oil® vs. insects, wounds viruses, bacteria, snake venom and orbital fractures

Posted on: March 23rd, 2017 | No Comments

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Chronic pain seems to be more common than diseases themselves.  Since my wife and I developed our product St. Jude’s Miracle oilTM, we really were surprised to see the results and customers became repeat customers.  So what is a measuring gage on our product?  First, of course we do not make medical claims of cures as it is listed in the disclaimer section elsewhere on our website.  Our goal was to develop a relief for inflammation.  We literally are in a living computer because we keep learning something new about our product each year.  What are some results we review here that you can find more in depth details elsewhere on the blog?  We have many consumers that ask how to apply the oil, and basically you can read the instuctions, which is either topical or inhale.  We do not suggest swallowing the oil as essential oils can be issues when ingesting.

Below I will present a review on many of our research subjects, and testimonials.  But here are things we have been notified by consumers regarding the effects including before and after photos and links:

SJMO  vs. Mosquitoes

SJMO vs. wounds

SJMO  vs. Mosquitoes

SJMO vs. viruses, MDR bacteria, MRSA, Staph, E coli, Pseudomonas, Candida

Essential oils research on wounds, burns

St Jude’s Miracle Oil® test against Canine rash (Staphylococcal Dermatitis & Hypersensitivity in Dogs)

Antivenom, EO vs. snake venom

Miracle oil client testimony of orbital fracture five day swelling

To our consumers, if it had not been for you, we would never have had the motivation to develop this incredible product.  It is your feedback and photos, testimonies and repeat customers that made this product St Jude’s Miracle Oil® what it is today.  Thank you, enjoy the article and share it with other consumers!  We look forward in the future to in depth studies with more funding and projects.

William Vandry

Information within this site is for educational purposes only. The U.S. Food & Drug Administration has not evaluated statements about the product efficacy. These products are not intended to diagnose, treat, cure, or prevent any disease.

SJMO  vs. Mosquitoes

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Peppermint essential oil is proved to be efficient larvicide (1). Eucalyptus, geranium, and lavender together without any other oils in this study are a very effective mosquito repellent(2). Frankincense(3) and Myrrh(4) are lethal to larvae of mosquitos. Perhaps a diluted SJMO with water or oil to rub or spray may repel mosquitos! We would love to do more studies on mosquito bites and our oil. In the picture section of this website, it does show how the SJMO reduces mosquito bites within a short time.

SJMO vs. wounds

32 hours deep wound almost gone.

sjmo after9 sjmo after2

Effect of myrrh (Commiphora molmol) on leukocyte levels before and during healing from gastric ulcer or skin injury.  Myrrh (Commiphora molmol) has been widely used as an anti-inflammatory and wound healing commercial product(5)

In addition to anti-inflammatory effects, Frankincense has been shown to have wound healing, antiulcer, and anti-diarrheal properties.(6)

From PubMed, this paper reports on a literature review of evidence on the influence of essential oils on wound healing and their potential application in clinical practice. It focuses mainly on tea tree, lavender, chamomile, thyme and ocimum oils. (7)

Among the PubMed claims made for lavender oil are that is it antibacterial, antifungal, carminative (smooth muscle relaxing), sedative, antidepressive and effective for burns and insect bites. (8)

This study on PubMed compared the effects of transcutaneous electrical nerve stimulation (TENS), saline solution (SS), povidone-iodine (PI), and lavender oil (Lavandula angustifolia) through expression of growth factors in a rat model of wound healing. Wound closure progressed more rapidly in the TENS and lavender oil groups than in the control and other study groups.(9)

Essential oils vs. viruses, MDR bacteria, MRSA, Staph, E coli, Pseudomonas, Candida

1. Peppermint effect on Influenza, viruses

2. Eucalyptus antibacterial effect against multidrug-resistant (MDR) bacteria

3. Lavender effect against MSSA and MRSA

4. Patchouli, tea tree, geranium, lavender essential oils and Citricidal (grapefruit seed extract) anti-bacterial activity 5. Thyme and Eucalyptus effect against MRSA

6. Lavender against antibiotic-restistant bacteria

7. Lavender oil, petigrain oil, clary sage oil, ylang ylang oil and jasmine combination against Staph 8. Antimicrobial activity of geranium oil against clinical strains of Staphylococcus aureus

9. Essential oils (including Eucalyptus, Lavender, Clove Bud, Peppermint) effective antiseptic topical treatment for MRSA and antimycotic-resistant Candida species

10. Black pepper, cananga, and myrrh oils have potential against Staphylococcus aureus 11. Myrrh antibacterial, antifungal activity against pathogenic strains E coli, Staph, Pseudomonas and Candida

12. Frankincense (Boswellia serrata) effective against Staphylococcus 13. Wintergreen acts as an anti-inflammatory and antimicrobial agent

Essential oils research on wounds, burns

Consumer sent us photo of 11 year old son with 2nd degree motorcycle burn, SJMO applied topically, day 20 seems to be gone.

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1, Burns and Wounds

2. Medical journals essential oils wounds and burns

3. SJMO wound tests

4. Medical references

Essential oils research on wounds, burns

St Jude’s Miracle Oil® test against Canine rash (Staphylococcal Dermatitis & Hypersensitivity in Dogs)

Canine rash due a form of Staph, relief within minutes, and 12 days later completely gone

 

Staphylococcus

SJMO test on my dog with Staph Dermatitis

How is Staphylococcal hypersensitivity treated on dogs?

SJMO oils reference studies using same oils on Dog rashes, infections, parasites, mites, ticks, fleas

References

St Jude’s Miracle Oil® test against Canine rash (Staphylococcal Dermatitis & Hypersensitivity in Dogs)

Antivenom, EO vs. snake venom

Rattlesnake bite on dog, necrosis is evident on June 15, 2016, second photo after SJMO topically applied shows necrosis appears to be reversed and wound is healing

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SJMO vs. Bee Sting

SJMO vs. Woman with RA having reaction to Mosquito bite

1. EO in SJMO vs. Shock

2. EO in SJMO vs. Coagulation of human plasma

3, EO in SJMO vs. Cytotoxic venom

4. EO in SJMO vs. Necrosis

Antivenom, EO vs. snake venom

Miracle oil client testimony of orbital fracture five day swelling

1/30/15 – 2/4/15 five orbital fractures due to baseball injury, no surgery yet, yet pain and inflammation gone

 

Miracle oil client testimony of orbital fracture five day swelling

Military First aid manual, can SJMO be added?

Military First aid manual, can SJMO be added?

Sources of reference:

1. Asian Pac J Trop Biomed. 2011 Apr;1(2):85-8. doi: 10.1016/S2221-1691(11)60001-4.Bioefficacy of Mentha piperita essential oil against dengue fever mosquito Aedes aegypti L.Kumar S, Wahab N, Warikoo R.

Source Department of Zoology, Acharya Narendra Dev College (University of Delhi), New Delhi-110019, India.

2. J Med Entomol. 2006 Jul;43(4):731-6. Repellency of oils of lemon eucalyptus, geranium, and lavender and the mosquito repellent MyggA natural to Ixodes ricinus (Acari: Ixodidae) in the laboratory and field. Jaenson TG, Garboui S, Palsson K.

Source Medical Entomology Unit, Department of Systematic Zoology, Evolutionary Biology Centre, Uppsala University, Norbyvägen 18d, SE-752 36 Uppsala, Sweden.

3.Parasitol Res. 2006 Sep;99(4):473-7. Epub 2006 Apr 27. Persistency of larvicidal effects of plant oil extracts under different storage conditions. Amer A, Mehlhorn H.

Source Omar Almukhtar University, P.O. Box 919, Elbieda, Libya. [email protected]

4. J Egypt Soc Parasitol. 2000 Apr;30(1):101-15. Larvicidal activity of Commiphora molmol against Culex pipiens and Aedes caspius larvae.Massoud AM, Labib IM.

Source: Larvicidal activity of Commiphora molmol against Culex pipiens and Aedes caspius larvae.Massoud AM, Labib IM.

5. http://www.ncbi.nlm.nih.gov/pubmed/19995243

6. Rahimi R, Shams-Ardekani MR, Abdollahi M. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol. 2010;16:4504–14. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924999/

7. J Wound Care. 2007 Jun;16(6):255-7. http://www.ncbi.nlm.nih.gov/pubmed/17722522

8. Phytother Res. 2002 Jun;16(4):301-8. http://www.ncbi.nlm.nih.gov/pubmed/12112282

9. Evid Based Complement Alternat Med. 2013;2013:361832. doi: 10.1155/2013/361832. Epub 2013 Jun 3 http://www.ncbi.nlm.nih.gov/pubmed/23861704

EO vs viruses, etc.

1. Peppermint effect on Influenza, viruses http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957173/

2. Eucalyptus antibacterial effect against multidrug-resistant (MDR) bacteria http://www.ncbi.nlm.nih.gov/pubmed/21591991

3. Lavender effect against MSSA and MRSA http://www.ncbi.nlm.nih.gov/pubmed/19249919

4. Patchouli, tea tree, geranium, lavender essential oils and Citricidal (grapefruit seed extract) anti-bacterial activity

5. Thyme and Eucalyptus effect against MRSA

6. Lavender against antibiotic-restistant bacteria

7. lavender oil, petigrain oil, clary sage oil, ylang ylang oil and jasmine combination against Staph

8. Antimicrobial activity of geranium oil against clinical strains of Staphylococcus aureus

9. Essential oils (including Eucalyptus, Lavender, Clove Bud, Peppermint) effective antiseptic topical treatment for MRSA and antimycotic-resistant Candida species http://www.ncbi.nlm.nih.gov/pubmed/19473851

10. Black pepper, cananga, and myrrh oils have potential against Staphylococcus aureus

11. Myrrh antibacterial, antifungal activity against pathogenic strains E coli, Staph, Pseudomonas and Candida

12. Frankincense (Boswellia serrata) effective against Staphylococcus

13. Wintergreen acts as an anti-inflammatory and antimicrobial agent

Military First aid manual, can SJMO be added?

Posted on: November 11th, 2016 |

 

Ukrainian soldiers learn battle skills such as first aid from U.S. Army troops at the International Peacekeeping and Security Center in western Ukraine.

Photo: Ukrainian soldiers learn battle skills such as first aid from U.S. Army troops at the International Peacekeeping and Security Center in western Ukraine.  Source: http://www.voanews.com/a/lviv-embraces-us-training-for-ukrainian-soldiers-/3086642.html

Ironically, with veterans I know, first aid came to a discussion last year.  I originally started writing this article earlier this year on Military first aid.  Since today is Veterans day 2016, I decided to finish it.

Salute to Veteran’s day!

What is the object of first aid?  From: http://www.mydaforms.com/study/FirstAid.html

To stop bleeding

First aid bleeding under military is:

  1. Field dressing
  2. Manual pressure
  3. Digital pressure
  4. Tourniquet

Overcome shock

From: http://www.armystudyguide.com/content/SMCT_CTT_Tasks/Skill_Level_1/0818311005-sl1-perform-fi.shtml

Standards: Attempted to prevent a casualty from going into shock by:

  1. Correctly positioning the casualty
  2. Loosening binding clothes
  3. Calming and reassuring ;
  4. and providing shade from direct sunlight during hot weather, or covering to prevent body heat loss during cold weather.

Relieve pain

http://consumer.healthday.com/encyclopedia/first-aid-and-emergencies-20/emergencies-and-first-aid-news-227/first-aid-for-pain-644845.html

First Aid for Pain (By Chris Woolston, M.S.)

When treating an injury, relieving pain should also be a top priority.”

  1. Prompt treatment for pain will make an injured person feel more calm and comfortable.
  2. Pain relief may also make it possible for the person to move safely on her own — a handy thing if the nearest phone is miles away.
  3. Pain can also be a guide to treatment.

Woolston states stocking  a first aid kit with:

Over-the-counter pain relievers such as acetaminophen or nonsteroidal anti-inflammatory agents (NSAIDs) such as ibuprofen.

– Instant-activating cold packs to treat the pain of insect bites, bruises, and scrapes.

– Cold packs can also be applied to sprains and strains.

– Gauze, adhesive tape, and scissors will make it possible to properly dress burns, and elastic wraps, such as

– ACE bandages, can be used to wrap injuries to muscles, joints, or bones.First- and second-degree burns.

– Run cool water over the burn to soothe the pain. (Don’t use ice or cold packs, because they could slow blood flow and make the injury worse.)

Cover the burn with sterile gauze.  Sprains, strains, dislocations, and fractures.

– RICE — rest, ice, compression, and elevation — is the best first aid strategy for painful injuries to muscles, joints, and bone injuries.  Bruises and scrapes.

– Gently clean areas with broken skin with cool water and cover them with a bandage.

– Hold a cold pack on the area to reduce pain and swelling.

Cuts

– Minor cuts simply need to be washed with soap and water, treated with an antibiotic ointment, and covered with a clean bandage.

Apply pressure if the bleeding doesn’t stop on its own after a few minutes.

– Seek prompt medical help if the cut is still bleeding after 10 minutes, if the wound is very dirty, or if you think stitches will be necessary.

Stings

– Wash the area with soap and water, then apply ice or a cold pack to reduce pain and swelling.

– Apply a cold compress, and use topical steroid ointments or oral antihistamines to relieve itching if needed.

– Apply a 1 percent hydrocortisone ointment, which is available over the counter, if the itching is significant, or an antihistamine. (Diphenhydramine (Benadryl))

Prevent infection

Infections are a primary cause of concern in first aid.  From: First Aid Care for Surgical Wound Infections.

Treatment

Care for surgical wound infections will usually require antibiotic therapy.  Over-the-counter or prescription pain killers may also be recommended. Depending on the infection, the doctor may need to remove the sutures and drain the wound.  A debridement procedure may be necessary to remove dead tissue preventing healing.

SJMO potential

Photo: SJMO consumer sends on her son’s motorcycle burns on his legs.  Miracle oil she applied to the wound and she sent second photo to post on facebook page: https://www.facebook.com/photo.php?fbid=1501590526814283&set=g.132501736829734&type=1&theater

The potential for SJMO product to assist as a supplemental addition to first aid for the Military referring to the above needs to stop bleeding can be referenced to a previous article regarding wounds and burns.1  The article covers wounds and a list of the medical references:

Wound infection

All open wounds are contaminated with bacteria, sometimes leading to wound infection which is a scourge to patients and caregivers, with some estimates as high as 30% of wounds affected.2

Wound treatment methods

Development of wound treatment methods were developed in 2001.  At that time there were no guidelines for palliative wound care, and wound healing was seen as an unrealistic goal of treatment in this patient population.3  What are general pain methods?  Nothing in the literature was found to either support or contradict use of lidocaine in the wound bed for pain relief, yet it is known that topical lidocaine can decrease pain.4

Topical antiseptics and antimicrobials

The NCBI and Pubmed medical journals show although it is established through in vitro studies that many of the antiseptic agents have cytotoxic properties.  (Toxic to cells)5

Antimicrobials are available in various forms for topical use and the most commonly used ones are Bacitracin A, Neomycin, Fucidin, Mupirocin, Retapamulin.  These serve as moist dressings.  However, because of its extensive use the incidence of resistance to mupirocin (Staphylococcus aureus (MRSA) infection) is also increasing, to the rate of 11-65%.6

If we look at essential oils, and specifically the ones in the SJMO product, compare medical sources.

Pain

Wintergreen  Oil is 85%-99% methyl salicylate which is aspirin-like and can contribute to pain relief as promoted in commercial literature.7

Anti-inflammatory, analgesic and wound healing

Myrrh (Commiphora molmol) has been widely used as an anti-inflammatory and wound healing commercial product.8  This complimentary study also discusses the use of myrrh in wound management.9  Myrrh oil has anti-inflammatory and analgesic activity in wound management.10  Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha.11,12

Frankincense has been shown to have wound healing, anti-ulcer, and anti-diarrheal properties.  Frankincense was used for symptomatic knee osteoarthritis.13

Lavender shows evidence on the influence of essential oils on wound healing and their potential application in clinical practice.  It focuses mainly on tea tree, lavender, chamomile, thyme and ocimum oils.14

Antibacterial, antifungal, relaxing, antidepressive, burns and insect bites

Among the PubMed claims made for lavender oil are that is it antibacterial, antifungal, carminative (smooth muscle relaxing), sedative, antidepressive and effective for burns and insect bites.15

This study on PubMed compared the effects of lavender oil (Lavandula angustifolia) through expression of growth factors in a rat model of wound healing.  Wound closure progressed more rapidly in the TENS and lavender oil groups than in the control and other study groups.16

Anti-microbial and anti-fungal

A natural polymeric composite films made of essential oils (EOs) dispersed in sodium alginate (NaAlg) matrix, with remarkable anti-microbial and anti-fungal properties. Namely, lavender, peppermint, eucalyptus and other oils were encapsulated in the films as potential active substances.17

Anti-agitation properties

Lavandula angustifolia and Melissa officinalis with anti-agitation properties: data suggest that components common to the two oils are worthy of focus to identify the actives underlying the neuronal depressant and anti-agitation activities reported.18

Labor/pregnancy episiotomy wound care

Healing advantages of lavender essential oil during episiotomy recovery: a clinical trial.  This study suggests application of lavender essential oil instead of povidone-iodine for episiotomy wound care.19

Antimicrobial activity on MSSA and MRSA

The antimicrobial activity of high-necrodane and other lavender oils on methicillin-sensitive and -resistant Staphylococcus aureus (MSSA and MRSA).20

Anti-inflammatory and analgesic

Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill.21

Pain relief on outpatients with primary dysmenorrhea

Lavender (Lavandula officinalis), clary sage (Salvia sclarea) and marjoram used.  All outpatients used the cream daily to massage their lower abdomen from the end of the last menstruation continuing to the beginning of the next menstruation.22

Pathogens, pain and wound treatment

Geranium oil  In this study the tested geranium oil was efficacious against Gram-negative pathogens responsible for problems with wound treatment.  The results suggest that geranium oil may be considered an effective component of therapy in the case of frequent recurrences of infections caused by resistant pathogens.23

The effect of essential oils on methicillin-resistant Staphylococcus aureus using a dressing model.  Geranium used with two others.  This study demonstrates the potential of essential oils and essential oil vapors as antibacterial agents and for use in the treatment of MRSA infection.24

Geranium has shown temporary relief of neuralgia pain.25

Clary sage oil may be applied to treat wounds and skin infection.26

Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species.27

Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats.28

Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus.29

We would like to see if we can get the funding to do a project with the Military and our SJMO.  We would hope to do a trial test one day on a CAM therapy, and definitely to discuss more on hopeful projects.

William Vandry

References 1-29:

1.http://www.stjudesmiracleoil.com/essential-oils-research-on-wounds-burns-2/

2.Lindholm C. Pressure Ulcers and Infection-Understanding Clinical Features. Ostomy Wound Manage. 2003;49(5): 4-7. – See more at: http://www.woundsresearch.com/article/palliative-wound-treatment-promotes-healing#sthash.gcCu3Nsi.dpuf

3.Rinne C. Laying the foundation: the multidisciplinary approach to program development. Paper presented at: Southwest Missouri State University, Four-Day Wound Management Workshop; September 2001; Warrensburg, MO. – See more at: http://www.woundsresearch.com/article/palliative-wound-treatment-promotes-healing#sthash.gcCu3Nsi.dpuf

4.Christensen T, Thorum T, Kubiak E. Lidocaine analgesia for removal of wound vacuum-assisted closure dressings: a randomized double-blinded placebo-controlled trial. J Orthop Trauma. 27(2):107-112 – See more at: http://www.woundsresearch.com/article/palliative-wound-treatment-promotes-healing#sthash.gcCu3Nsi.dpuf

5.Lineaweaver W, Howard R, Soucy D, Mc Morris S, Freeman J, Crain C, et al. Topical antimicrobial toxicity.Arch Surg.1985;120:267–70. [PubMed]

6.Mathieu et al., 2006; Menke et al., 2007 Wintergreen essential oil same as birch? www.experience-essential-oils.com/wintergreen-essential-oil.html. – See more at: http://www.woundsresearch.com/article/palliative-wound-treatment-promotes-healing#sthash.gcCu3Nsi.dpuf Curr Med Chem. 2003 May;10(10):813-29.

7.Antibacterial and antifungal properties of essential oils. Kalemba D, Kunicka A.SourceInstitute of General Food Chemistry, Technical University of Lodz, Poland.

8.Effect of myrrh (Commiphora molmol) on leukocyte levels before and during healing from gastric ulcer or skin injury http://www.ncbi.nlm.nih.gov/pubmed/19995243

9.Integrating complementary and alternative medicine: use of myrrh in wound management. Walsh ME 1, Reis D, Jones T. http://www.ncbi.nlm.nih.gov/pubmed/20709267

10.Analgesic, anti-inflammatory and anti-hyperlipidemic activities of Commiphora molmol extract (Myrrh), http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576796/

11.Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha. http://www.ncbi.nlm.nih.gov/pubmed/21167270

12.Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha. Source: Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046, PR China., A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol. 2010;16:4504–14. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924999/

13.Chopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A, Narsimulu G, et al. Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: A randomized, double-blind, controlled equivalence drug trial. Rheumatology (Oxford) 2013;52:1408–17. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175880/

14.The influence of essential oils on the process of wound healing: a review of the current evidence, http://www.ncbi.nlm.nih.gov/pubmed/17722522

15.Biological activities of lavender essential oil. http://www.ncbi.nlm.nih.gov/pubmed/12112282

16.A Comparison Study of Growth Factor Expression following Treatment with Transcutaneous Electrical Nerve Stimulation, Saline Solution, Povidone-Iodine, and Lavender Oil in Wounds Healing http://www.ncbi.nlm.nih.gov/pubmed/23861704

17.All-natural composite wound dressing films of essential oils encapsulated in sodium alginate with antimicrobial properties. http://www.ncbi.nlm.nih.gov/pubmed/24211443

18.Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels. http://www.ncbi.nlm.nih.gov/pubmed/18957173

19.Healing advantages of lavender essential oil during episiotomy recovery: a clinical trial. http://www.ncbi.nlm.nih.gov/pubmed/21168115

20.The antimicrobial activity of high-necrodane and other lavender oils on methicillin-sensitive and -resistant Staphylococcus aureus (MSSA and MRSA). http://www.ncbi.nlm.nih.gov/pubmed/19249919

21.Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of lavandula angustifolia mill. Journal of Ethnopharmacology, 89(1), 67-71.(Lavender), http://www.sciencedirect.com/science/article/pii/S0378874103002344

22.Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial http://www.ncbi.nlm.nih.gov/pubmed/22435409

23.The antibacterial activity of geranium oil against Gram-negative bacteria isolated from difficult-to-heal wounds http://www.ncbi.nlm.nih.gov/pubmed/24290961

24.The effect of essential oils on methicillin-resistant Staphylococcus aureus using a dressing model http://www.ncbi.nlm.nih.gov/pubmed/15555788

25.Temporary relief of postherpetic neuralgia pain with topical geranium oil. American J of Medicine, 115, 586-587. The antibacterial activity of geranium oil against Gram-negative bacteria isolated from difficult-to-heal wounds. http://www.ncbi.nlm.nih.gov/pubmed/24290961

26.The effect of clary sage oil on staphylococci responsible for wound infections. http://www.ncbi.nlm.nih.gov/pubmed/?term=Wounds+clary+sage+oil

27.Antifungal activity of the clove essential oil from aromaticum on Candida, Aspergillus and dermatophyte species Euge´ nia Pinto,1 Luı´s Vale-Silva,1 Carlos Cavaleiro2 and Lı´gia Salgueiro2, http://www.ncbi.nlm.nih.gov/pubmed/19589904 SAA no. 8

28.Phytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats http://www.ncbi.nlm.nih.gov/pubmed/?term=ical+composition+of+Cymbopogon+citratus+and+Eucalyptus+citriodora+essential+oils+and+their+anti-inflammator

29.Antibacterial activity of the essential oils from the leaves ofEucalyptus globulusagainst Escherichia coli and Staphylococcus aureus http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609378

Further Resources

Thygerson, Alton L., Thygerson, Steven M., and Thygerson.Matthew L. American Academy of Orthopaedic Surgeons (AAOS). Wilderness First Aid Field Guide. Jones and Bartlett. 2006

Duke University Medical Center. Stocking a first-aid kit. http://www.dukemednews.org/news/healthtip.php?id=5710

National Safety Council. First Aid & CPR. http://www.nsc.org/safety_home/FirstAidCPR/Pages/Firstaid_CPR.aspx

Arthritis Foundation. First aid with R.I.C.E. http://www.arthritis.org/resources/SIP/RICE.asp

Massachusetts General Hospital. Basic burn care/first aid burn treatment. http://www.massgeneral.org/burns/patients/

Mayo Clinic. Burns: first aid. January 2005. http://www.mayoclinic.com/health/first-aid-burns/FA00022

The Harvard Medical School Family Health Guide. How to splint a fracture. http://www.health.harvard.edu/fhg/firstaid/splint.shtml

Mayo Clinic. Dislocated shoulder when to seek medical advice. http://www.mayoclinic.com/health/dislocated-shoulder/DS00597/DSECTION=5

American Academy of Family Physicians. Cuts, scrapes, and stitches: caring for wounds. http://familydoctor.org/online/famdocen/home/healthy/firstaid/after-injury/041.html

Mayo Clinic. Insect bites and stings: first aid. http://www.mayoclinic.com/health/first-aid-insect-bites/FA00046

Nemours Foundation. Insect stings and bites. http://kidshealth.org/parent/firstaid_safe/emergencies/insect_bite.html

Mayo Clinic. Cuts and Scrapes: First Aid. January 2008. http://www.mayoclinic.com/health/first-aid-cuts/FA00042

Miracle oil client testimony of orbital fracture five day swelling

Posted on: September 16th, 2016 |

     

1/30/15 broken eye socket          2/4/15 bruise reduced, swelling appears gone

Five days!

I was contacted by a Chiropractor that sells our product at her office.  She notified me that one of her patients wanted to contact me regarding our Miracle oil product.  She handed me a note with her patient’s contact information.  The Chiropractor notified me that this woman’s son had endured a baseball injury from a baseball that hit him in his orbital socket.  It had broke the socket, and inflammation and pain were unbearable.  She added that her patient stated she wanted to contact me with photos verifying the reduction of swelling and pain within a relatively short period of time.  I called her patient the next day.  Her name is Heather.  Heather was very excited to tell me how the product helped her son’s eye injury healed so fast.  She notified me of the below photos timeline:

1/30/15 baseball pop fly injury.

1/31/15, 8 hours later the eye swelling is not as prominent after applying Miracle oil.

2/2/15, almost 60 hours later the eye swelling is almost normal, excluding the bruising and scrape.

2/4/15, appointment with surgeon showed he had five breaks in the socket.  Excluding bruising and scab, the eye swelling appears normal.

What is an orbital socket injury?

Eye-Socket Fracture (Fracture Of The Orbit)

The eye socket is a bony cup that surrounds and protects the eye.  The rim of the socket is made of fairly thick bones, while the floor and nasal side of the socket is paper thin in many places.  A fracture is a broken bone in the eye socket involving the rim, the floor or both.  Orbital rim fracture — These are caused by a direct impact to the face, most commonly by an automobile dashboard or steering wheel during a car crash.1

 Healing Time of Orbital Fracture

The healing time of orbital fracture depends on the severity and location of the fracture.  In majority of the cases of orbital fracture, the discoloration and swelling begin to subside within a week to 10 days after the injury has occurred.  However, the fractured orbital bones take a longer time to heal.  If surgery is needed to repair the orbital fracture, then the doctor will wait for several weeks before operating, to allow the swelling to subside.2

I have a facial fracture, how long will it take to heal?

How long it takes a facial fracture to heal will depend on the type and extent of fracture and what other problems and treatment you had.  Bruising and swelling usually takes 2 to 3 weeks to settle down.  At this point, you will begin to look more normal.  After this time the body will continue to heal itself inside. Unfortunately, you will need to be a patient.3

NBA players orbital injuries two weeks no activity

According to In Street Clothes writer Jeff Stotts,  Jason Terry, Joe Johnson, Tarence Kinsey and Etan Thomas are four NBA players that recently suffered orbital fractures that required surgery.  Collectively as a group, they missed an average of 14 games (about two weeks).4

Considering the weeks and months it normally takes to reduce swelling and inflammation, the testimony from the parent gives a hopeful possibility for orbital injury swelling.5  Enjoy it below!

William Vandry

References:

1. http://www.health.harvard.edu/diseases-and-conditions/eye-socket-fracture-fracture-of-the-orbit

2. http://www.epainassist.com/sports-injuries/head-and-face-injuries/orbital-fracture

3. http://www.cuh.org.uk/addenbrookes-hospital/services/oral-and-maxillofacial-surgery-and-orthodontics/facial-fractures

4. http://dawindycity.com/2015/09/30/chicago-bulls-news-the-facts-about-orbital-fractures/

5. Testimony from parent Heather Watson.

______________________________________

My testimonial. The proof is in the oil!! St Jude’s Miracle Oil that is!!!

Hi William,
Thanks for reaching out and spending so much time talking with me! The wealth of information is greatly appreciated! Below is the success I had using your oil on my son.

 

The 2 pictures above were taken at approximately 10:30pm on 1/30/15, Friday, about 3 hours after he took a 60mph pop fly to the eye.  We got home from the hospital at 4am and around then I applied miracle oil just under the eye and on the eyelid.


This is 1/31/15 the morning after applying 1 time. (About 8 hours after applying once!!) 😊 His eye is open!!
The following 3 pictures were taken that Monday, 2/2/15 which was 60 hours of the 1st application and after applying 2 times per day for the weekend.

So much swelling has been reduced!


In my opinion it reduced the swelling by more than 50%

Side view of the MAGIC!!!

These last 2 were taken 2/4/15. We saw the surgeon this day. These were actually taken at his office. In the initial exam they told us he had broken the orbital socket in 2 places. On 2/4/15 we learned there were actually 5 breaks but because of all the swelling it wasn’t visible in the 1st x-ray. Pretty powerful stuff!!!!


Sent from my iPhone

Antivenom, EO vs. snake venom

Posted on: July 18th, 2016 |

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“The average cost per vial for veterinary purchase is $300.00.  Other F(ab’)2 products from Brazil and Venezuela are available, however there is no current published peer reviewed veterinary literature on these products.   Stay tuned for future veterinary studies, as clinical trials are underway. ”

– Dr. Raegan J. Wells, DVM, MS, DACVECC, an Assistant Professor of Emergency and Critical Care Medicine at Colorado State University

July 16, 2016

Recently, a good friend unfortunately had a dog that was bitten by a rattlesnake.  His dog had been taken to a vet ER, injected with an antivenom, antibiotics, etc. but later had died.  He added that the dog and another dog lived in the country area.  The country area is known for venomous snakes such as rattlesnakes, copperheads and so on.  The second dog too was bitten by the rattlesnake.  I asked him was it still alive?  He stated yes, but it wasn’t doing well after being bit, and had similar inflammation, swelling, lethargy, pain, etc. to the other dog before it died.  This was the next day, and he texted me a photo of the 2nd dog’s leg still alive showing the rattlesnake bite, swelling and infection.  I told him venomous creatures such as snakes and scorpions are administered a type of anti-venom or a vaccination by vets or ER for humans.  This did not help the first dog, as it had passed away.  The second dog’s bite was becoming necrotic on the wound but had not been taken to the vet for a similar treatment yet.

To understand how Antivenom works, we need to understand how venom works.

1. Venom is made of a mixture of proteins and each can individually produce a different response.

2. For example, crotalid neurotoxins block Neuromuscular junction, by acting on acetycholine receptors  (Mechanisms of Venom Toxicity)

3. Another example is Chlorotoxin, found in the venom of the Deathstalker.

NOTE: The deathstalker (Leiurus quinquestriatus) is a species of scorpion, a member of the Buthidae family.  It is also known as the Israeli Yellow scorpion.  This toxin is a potassium, chloride channel toxin, i.e it binds and blocks these ion channels. (Chloride channel inhibition by the venom of the scor… [Toxicon. 1991])

Anti-venom consists of Antibodies, (so, one is getting injected with antibodies for a particular venom), they bind to the venom and chemically change it to something that can not interact with the body, thus neutralizing its effects.  That being said, they usually can not reverse any effects of the venom.  This is a form of Passive immunity.  Technically, one’s body can produce the antibody on its own, but the response of the immune system is a lot slower vis-a-vis venom.  Hence anti-venoms, an external source of antibodies is needed to counter the effect of venom.1

Why Not Rattlesnake Vaccine?

I researched to find critics on rattlesnake venom and to my surprise from Austin, Veterinarian Dr. Will Falconer’s (DVM) website here are quotes:

“The rattlesnake vaccine is of questionable efficacy.  The manufacturer, Red Rock Biologics shows no study data to support efficacy at all.”

“Immunologists and UC Davis Vet School don’t think it’s worthy of recommending.  A colleague of mine, practicing in snake country in So. California, relayed that Dr. Michael Peterson, DVM, MS, an expert in venom and snake bites, thinks the vaccine is a joke, and it was “laughed off the stage” at a human medical conference.”

“If there’s immunity from this vaccine at all, it’s short lived. Some months, perhaps. Even the maker admits this.”

“Another point against its efficacy: the manufacturer urges the same rush to the ER and same intensive treatment whether your dog has had this vaccine or not when he received his snake bite.”

“Then there’s the safety question.  As with all injections of foreign protein into an animal’s body, you really have to question the wisdom of such a procedure.  Abscesses at the injection site have been reported, and here’s a case of autoimmune disease I found that came right after rattlesnake vaccination, with denial by the manufacturer at every turn.”

“Rattlesnake vaccine is also quite expensive, often running $40 or more a shot, and a series is recommended. “2

“Snake Oil”

Dr. David Stewart originally pursued a college major in theology, philosophy, and English, and earned degrees in physics, math, earth science, and natural medicine.  He is a Registered Aromatherapist.  Dr. Stewart wrote on the origin of the work snake oil:

“Snake Oil” is a term coined during pioneer days in the United States that became a synonym for fraud. Actually “snake oil” was a legitimate product sold by traveling salesmen throughout the frontier West as a first aid remedy for rattlesnake bites.  Applying the oil on the site of the bite would react chemically with the venom and render it harmless.  It worked.  The essential oil was Tea Tree (Melaleuca alternifolia).  Unfortunately, not all salesmen were honest and some were selling just any old cheap oil in a bottle and calling it “snake oil.” When people discovered that it did not work, all snake oil salesmen were branded as untrustworthy.  In the late 1900s and early 20th century, when it became known that some essential oils promoted as effective snake bite remedies did not work and had been sold by deception, drug companies spread another fraud saying that natural remedies, in general, were unscientific and did not work while the synthetic potions they manufactured were scientific and better.  Hence, even to this day, those of us who promote natural remedies are sometimes called “snake oil salesmen” as a put down for our practice and our products.

The U.S. Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) have found that spraying or diffusing Cinnamon and/or Clove oil into a container will repel snakes and drive them out.  It does not kill them, but just makes it unpleasant enough to force them to leave. Applying the oils in advance does not prevent snakes from crawling over those surfaces and entering hiding places that could pose hazards to humans.  The oils must be applied directly to or in the vicinity of the snakes themselves.  When a brown snake emerges from a shipment, they can control its movements and facilitate its exodus by simply aiming a stream of spray from a bottle containing a mixture of 1% clove or cinnamon oil, with 1% sodium lauryl sulphate (as an emulsifier), and 98% water.  The stream must hit the snake in the head to trigger escape behavior and effectively control its movements.”3

NOTE:  For more information on how and why essential oils work, see the book, The Chemistry of Essential Oils Made Simple – (God’s Love Manifest in Molecules) by Dr.David Stewart.

Snake bite

Snake bite causes a coagulopathy – a blood coagulation disorder, and this is the problem.   Clinically however, there has been some suspicion about the effectiveness of antivenom because it does not reverse the coagulopathy, initially resulting in larger and larger doses being given (up to 23 vials in this brown snake study).

The current recommendations are to use 1 vial only, because more doses are ineffective, and this recommendation is based on lab evidence (that has not translated into clinical effectiveness for other antivenoms).

This study showed that giving coagulation factors (FFP) was effective at treating snake bite coagulopathy, but the timing or dose of antivenom had no effect.4

The doctor from Australia that writes in his blog also references the ncbi source:

Failure of antivenom to improve recovery in Australian snakebite coagulopathy references this study:

RESULTS: Neither antivenom dose nor time of antivenom administration had an effect on recovery of VICC.

DISCUSSION: Antivenom did not appear to be effective for the coagulopathy in snake envenoming in Australia. FFP appeared to shorten the time of VICC recovery.5

And another NCBI study, Antivenom efficacy or effectiveness:

“Despite widespread use of antivenoms, many questions remain about their effectiveness in the clinical setting.  There are numerous potential reasons for antivenom failure in human envenoming, of which antivenom inefficacy is only one.  Other important reasons include venom-mediated effects being irreversible, antivenom being unable to reach the site of toxin-mediated injury, or the rapidity of onset of venom-mediated effects.  A number of recent studies in Australia bring into question the effectiveness of some antivenoms, including snake antivenom for coagulopathy, redback spider and box jellyfish antivenoms.  Despite brown snake antivenom being able to neutralise venom induced clotting in vitro, use of the antivenom in human envenoming does not appear to change the time course of coagulopathy.“6

 The numbers

1. There are up to 3,000 snake bites per year in Australia, of which about 1% get antivenom, but the deaths still number about 1 person per year.7

– The Australian Inland Taipan has been labelled the deadliest snake in the world, but there have never been any recorded deaths from this snake.  There has been no recorded death from spider bite in Australia since 1979.8

-Interestingly, this has been credited as due to the redback spider antivenom that has been shown to be ineffective.9

-More people die each year in Australia from bee stings than snakes and spiders put together.10

-Anaphylactic (severe allergic) reactions to snake antivenom are common.11

(Antivenom use, premedication and early adverse reactions in the management of snake bites in rural Papua New Guinea, and Current use of Australian snake antivenoms and frequency of immediate-type hypersensitivity reactions and anaphylaxis) and may be fatal.)

5. DMSO is another product that is used for snake bite venom at times.  DMSO is at times used in an IV, but with hopeful antioxidant purposes, not topical and studies show low success with snake venom.12

From pubmed DMSO vs. Snake venom:

1. Antiproteolytic activity of H. brasiliense

DMSO (1%, v/v, final concentration) did not interfere in proteolytic activity of B. jararaca.

NOTE: Proteolytic activity is the breaking down of proteins into simpler compounds, as in digestion.

NOTE: B. jararaca.is a species of pit viper endemic to southern Brazil,Paraguay, and northern Argentina.

2. Anticoagulant effect of H. brasiliense

DMSO alone did not interfere in clotting times.

3. Antihemolytic effect of H. brasiliense 

Neither HBSE alone induce hemolysis, nor the hemolytic activity induced by B. jararaca venom mixed with DMSO was affected.

NOTE: Hemolysis is the destruction or dissolution of red blood cells with release of hemoglobin.

4. Antihemorrhagic effect of H. brasiliense

DMSO did not interfere in B. jararaca-induced hemorrhage (Figure 5, column 2)

NOTE: Hemorrhage is excessive discharge of blood from the blood vessels; profuse bleeding.

My friend told me they tried to treat his dog the night it was bitten at a Veterinarian’s clinic.  There are different types of antivenom or what is known as antivenin.  Antivenom serums are for:

– Spiders

– Acarids (ticks)

– Insects (such as a venomous caterpillar from Brazil)

– Scorpions

– Marine animals

– Snakes

He sent me the treatments for the snakebite by the vet, and the antivenom used on his dog was Bioclon:

”This product (Bioclon) provides a new treatment for children and adults and is designed specifically for scorpion stings,” Midthun says. “Scorpion stings can be life-threatening, especially in infants and children.”13

I was a bit confused.  Why did his dog get injected with scorpion antivenom?  Snake antivenom or antivenin is limited, but it would seem that perhaps scorpion antivenom may not work against rattlesnake venom?  I will get back to this more at the end.

I remembered one thing about our Miracle oil.  There was a time a friend of mine was stung by a bee in 2015 when we were talking in a parking lot.  We removed the stinger, and he began to have the usual allergic reaction with swelling and shock.  It had an anti-histaminic effect.  Here are photos he took as it happened.

SJMO vs. Bee Sting

Before:

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After two hours later no reaction:

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It also had a similar effect on a woman I met at a wedding in 2015 that had Rheumatoid arthritis.  She was bitten by a mosquito, and due to her low immunity system, she had a similar allergic reaction to a mosquito bite.  We carry our oil everywhere we go for general reasons, and I applied a few drops on the mosquito bite.

SJMO vs. Woman with RA having reaction to Mosquito bite

Before:

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After app. 33 minutes:

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Granted, both above are hardly clinical trials, but they are on the job work and a type of a blind test.  I was pleased to see both had a recovery in about five minutes.  Bee stings and mosquito bites are not snake venom, but bee stings are treated at allergy centers and are a form of reaction scorpions, and snakes like other creatures listed above cause.

SJMO vs. Poison Ivy in 45 minutes

Similar to allergic reactions, here is an additional before and after of a consumer that was exposed to Poison Ivy while fencing a ranch in Louisiana:

Before:

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After:

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Main issues regarding venom or reactions to bee stings or reactions to snake venom are comparable.  I found research on essential oils with snake venom, although much more on clinical trials is needed to validate or even make any claims.  There are ncbi and pubmed medical journals I looked up for reactions to snakebites and any medical journals comparing possibilities our oils:

1. EO in SJMO vs. Shock

Peppermint studied with other oils as an alternative intervention in asthma, allergy and immunology.14

Peppermint and Eucalyptus oils on human and animal studies conclude anti inflammatory and analgesic effects occur.15

Results of Peppermint oil and relaxation of bronchial smooth muscles, increase in the ventilation and brain oxygen concentration, and decrease in the blood lactate level are the most plausible explanations on enhanced exercise performance with athletes.16

Peppermint and Eucalyptus on nausea and headache, secretolytic and and anti microbial effects.17

Eucalyptus application by either vapor inhalation or oral route provides benefit for both purulent and non-purulent respiratory problems, such as bronchitis, asthma, and chronic obstructive pulmonary disease (COPD).18

Eucalyptus globulus (E. globulus) which they find applications as anesthetic, anodyne, antiseptic, astringent, deodorant, diaphoretic, disinfectant, expectorant, febrifuge, fumigant, hemostat, inhalant, insect repellant, preventitive, rubefacient, sedative yet stimulant, vermifuge, for a folk remedy for abscess, arthritis, asthma, boils, bronchitis, burns, cancer, diabetes, diarrhea, diphtheria, dysentery, encephalitis, enteritis, erysipelas, fever, flu, inflammation, laryngalgia, laryngitis, leprosy, malaria, mastitis, miasma, pharygnitis, phthisis, rhinitis, sores, sore throat, spasms, trachalgia, worms, and wounds.19

Peppermint oil exhibited antispasmodic activity on rat trachea.20

2. EO in SJMO vs. Coagulation of human plasma

A medical journal compared Peppermint oil with platelet aggression or how clotting at times occurs on airline flights.  When the barometric pressure lowers, it induces platelet aggregation — the platelets clump together. It also says that Japanese peppermint oil inhibits this aggregation.21

Topical Methyl salicylate or Wintergreen oil significantly decreases platelet aggregation in healthy human volunteers.22

Study demonstrated antiplatelet properties of lavender oil towards platelet aggregation induced by arachidonic acid on guinea-pig platelet rich plasma (PRP) and its ability to destabilize clot retraction.23

Clove oil inhibited human platelet aggregation induced by arachidonic acid (AA), platelet-activating factor (PAF) or collagen. Clove oil was a more effective inhibitor for aggregation induced by AA and PAF.24

3, EO in SJMO vs. Cytotoxic venom

Cytotoxic venom is generally composed of several digestive enzymes and spreading factors, which result in local and systemic injury.  Clinically, local effects progressing from pain and edema to ecchymosis (bleeds under the skin) and bullae (watery blisters) most commonly predominate.  Hematological abnormalities including benign defibrination with or without thrombocytopenia (increased bleeding and decreased clotting) may result, but severe generalized bleeding is not common.  Pain and swelling occurs almost immediately after the bite from a cytotoxic snake and gradually becomes worse, in the next few hours. (Within 4 to 6 hours it will be more pronounced) It is often described as “cold fire” Later shock develops and this may cause death.25

Peppermint oil exhibited potent anti-inflammatory activities in a croton oil-induced mouse ear edema model.  It could also effectively inhibit nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.  The cytotoxic effect was assessed against four human cancer cells. MEO was found to be significantly active against human lung carcinoma SPC-A1, human leukemia K562 and human gastric cancer SGC-7901 cells, with an IC50 value of 10.89, 16.16 and 38.76 µg/ml, respectively. In addition, MEO had moderate antioxidant activity.26

Other countries are already doing trials on the Anti-hemolytic and Anti-cytotoxicity Effect of Two Essential Oil against Snake Venom.27

Let’s go back to my friend with the dog.  His dog was administered the above antivenom which is:

1. Designed for scorpions not rattlesnakes

2. Antibiotics also were added

3. Two other drugs for pain and swelling

4. EO in SJMO vs. Necrosis

In this study of essential oils countering tumor necrosis, geranium essential oils used as antiinflammatory remedies suppress neutrophil activation by TNF-a at a low concentration (0.0125/0.025%) in vitro, and was one of the strongest suppressing activity oils.  Lavender and Eucalyptus were also successful.  Lavender was not as effective as Geranium, yet its aid at countering necrossis from the study stated it could be explained by other mechanisms, because they also suppress degranulation of mast cells or cytokine production.  Remember cytotoxic venom above?

The study also states:

“it is possible that essential oils suppress the neutrophil adhesion through signal transduction below the receptor interaction to the ligands TNF and LPS in membrane, because the oils are known to affect the physiological condition of cell membranes.”

NOTE: Neutrophil is any cell, structure, or histologic element readily stainable with neutral dyes.

NOTE: Adhesion is a fibrous band or structure by which parts abnormally adhere.

And in addition, the above study showed DMSO (0.4%) to the medium has no significant effects on snake venom.27

Another example of cytotoxicity or the anti tumor effect of essential oils, NCBI has shown Frankincense oil appears to distinguish cancerous from normal bladder cells and suppress cancer cell viability.28

In addition, there are many out there that claim essential oils are toxic and can be harmful.  Some can, as they are not to be used as a drink.  Essential oils generally are applied topical or inhaled, but should not be taken orally or internally as a drink or food.29

Back to the rattlesnake bite, inflammation is a reaction that needs to be controlled.  Wintergreen has shown very strong effects against inflammation in an arthritis study30, and data elsewhere on this website shows other oils here have anti-inflammatory effects as well.

On humans, usually an ER gives an antivenom and tetanus shot.31

Dogs are given general antivenom, and the antibiotics and some pain medications.  On Pubmed, it references what types of antivenom are used for pit viper snakes, or in this case for rattlesnakes in the USA:

“…There is currently only one antivenom available in the United States for the treatment of pit viper envenomation,  Antivenin (Crotalidae) Polyvalent (ACP)…”32

Here Prednisolone was applied to dogs that had received rattlesnake bite.  These were the results:

– None of the dogs died during the study period.

– The mental status was reduced in 60/75 (80%) of dogs on Day 1, compared to 19/75 (25%) on Day 2.

– The proportion of dogs with no or only mild edema increased significantly from Day 1 to Day 2.

– About one-third of the dogs developed gastrointestinal signs during the study period.

– Cardiac arrhythmia was uncommon.

– Clinicopathological changes included increased total leucocyte count, CRP and troponin concentration on Day 2.

– The cTnI concentration was increased in dogs with systemic inflammation, compared to dogs without systemic inflammation.

– A single dose of prednisolone did not significantly affect any of the clinical or clinicopathological parameters studied, except for a higher monocyte count on Day 2 in dogs that had received prednisolone treatment.

The results in the study were:

“…The results of the present study do not support routine administration of a single dose of prednisolone 1 mg/kg subcutaneously in dogs bitten by Vipera berus…”33

The canine rattlesnake vaccine comprises venom components from Crotalus atrox (western diamondback).  In addition, it also states on the Animal Medical Center website specifically regarding this rattlesnake antivenom in the USA:

“The vaccine however does not provide protection against the Mojave rattlesnake, Eastern Diamondback rattlesnake, cottonmouths or coral snakes.”34

In a study of Current Treatment for Venom-Induced Consumption Coagulopathy Resulting from Snakebite, ultimately results showed:

Antivenom is the major treatment for VICC, but there is little high-quality evidence to support its effectiveness.”35

Why did his vet administer scorpion antivenom?  Perhaps he did not have a supply of specific rattlesnake venom, but only his ER vet knows best why.  Antivenom is made for spiders, or other creatures that have no relevance to snake venom or treatment.  Above research clearly prescribes rattlesnake vaccine from W. diamondback does not work for others.

Serotherapy vs. Snake venom

Serotherapy is a treatment that consists of the administration of specific serums that promote self-healing of our body whether through vitamins, nutrition or in this case snake venom.  In Sao Paulo, Brazil there was a study showing the authors report a case of bothropic envenoming in a male Cocker Spaniel.  The animal was bitten in the ventral thoracic region, receiving treatment 4 hours later.  Clinical examination revealed an extensive, painful and area of firm edema, absence of local or systemic hemorrhage, without evident neurological alterations.  Clinical diagnosis was mild bothropic envenoming.   Treatment consisted of 5 vials of polyvalent snake antivenom, two vials administered intravenously and three subcutaneously.

Blood clotting time was always within normal values.

Two days after envenoming, the animal showed hyperthermia and received enrofloxacin (5mg/kg/24h) for 10 days and ketoprofen (1mg/kg/24h) for 5 days.  Seventy-two hours after envenoming, extensive subcutaneous, muscle fiber, and skin necrosis of approximately 10 cm in diameter was observed.

After débridement of necrotic tissues, the area was cleaned with antiseptic solutions.  Complete healing was observed 55 days after envenoming.

The authors discuss whether heterologous serotherapy is effective in preventing tissue necrosis after bothropic envenoming:

“In conclusion, these results are in agreement with the generally accepted view that local tissue damage induced by snake venoms is difficult to prevent by serotherapy.”36

When my friend told me the second dog was still alive but  had the same effects as first dog, he mentioned that it had not been taken  to an ER by the owners yet.

I asked him had it been given anything, and he responded by stating the owners did not, hoping it would heal.  He told me he was visiting the family and dog to see an update that day.  I told him to bring a bottle of the Miracle oil with him and apply it immediately to the dog’s wounds in case of infection.

Since the dog had no treatment and was in pain and infected, I felt something may help, and our oil is not toxic to dogs when applied topically.  The other dog passed away the night before.  None of the shots above worked, as snake bites are attempted to be controlled where it doesn’t get worse with medications and the antibodies are used in the hope of countering the venom.  Back to his second dog.  He told me the dog was experiencing similar results from the rattlesnake bite, swelling, edema, bleeding, necrosis, etc.

He sent me notes on the history on both dogs, and he kindly shared them with me to post on this article:

6/10/2016- Irish Terrier “Bria” was bit in the late afternoon/early evening by a rattlesnake on face.  Snake was never found.

Bria was taken to emergency room in obvious pain- potentially several hours after bite occurance.  After treatment she became non-responsive, heavy breathing, and still in obvious pain when forced to take medication/liquids.

Note: Vet informed that the snake bite location on her face should not have effected breathing.

Treatment outline/prescriptions (1 pill given for Qty listed during time):

Description                                  Qty

Antivenen (Bioclon)/Vial                               1

Buprenex (0.3 mg/ml) Injection/ml          1

Cephalexin 250 mg. Capsules                      14

Tramadol HCL 50mg                                        30

Results: Bria was non-responsive/zombie-like immediately following initial treatment.  Taken home for the night.  Dead by morning- having never changed position.  Bria passed away by morning.

6/11/2016 a second pet was struck on the leg and possibly face (no facial marking, but large swelling)….snake was still not found.

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6/12/2016- SJMO applied- ears, stomach, paw pads- 3pm

6/15/2016- SJMO still being applied- ears, stomach, paw pads, around wound (not on wound directly though)- 1-2 times daily on average (Photo 2: Note scab necrosis, inflammation from rattlesnake venom)

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6/18/16SJMO applied on wounds bright pink, not necrotic, after three days of directly applying to wound as well as other areas

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6/19/16- SJMO application seems to have reduced swelling, infection and inflammation of rattlesnake bite:

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NOTE: photo above was last day SJMO was applied.  Owners purchased DMSO product to apply as a self remedy instead.

Close up shows wound is healing, good color, no necrosis, or dead tissue from scabbing.

7/1/2016- Informed by friend that owners purchased DMSO purchased at a Vet clinic, and has been applied to wound daily for about 10 days.  Informed SJMO was being applied the first 7-10 days and then was stopped.

7/4/2016- SJMO has not been used for weeks at this time.  Wound appears to have scabbed over/healing.

Side note: During course of treatment, owner discovered large cancerous tumor on stomach of dog.  Dog has irritated wound by scratching, post surgery/removal.

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NOTE: inflammation, dead tissue, clear swelling seems to have returned on dog.

In final, I do not know the current update of the dog and it’s rattlesnake bite toxicity level nor it’s condition.  We do see at least on an anecdotal trial, the SJMO seems to have improved the rattlesnake bite venom response comparing necrotic tissue and the bright pink wound later seeming to be healthier.  In speculation, we do not have any pure blind tests here, but perhaps the anti-inflammatory, anti-microbial, anti-histaminic and anti-bacterial agents of the essential oils in the SJMO (see references) may have been the improvement during the time it was used.  Unfortunately we will never know.  Consumers have used the oil for insect bites, and on pets we have referenced research on ticks, fleas, mosquitos and other insects.  Perhaps in the future we can also look at future clinical trials with certain essential oils and the efficacy on not only snake venom, but insects, ticks, marine animals, scorpions and others as well.

William Vandry

References

  1. https://www.quora.com/How-does-anti-venom-work-in-our-bodies-when-injected
  2. http://vitalanimal.com/rattlesnake-vaccine/
  3. http://www.allthingshealing.com/Aromatherapy/Essential-Oils-as-Snake-Repellents/7036#.V2lVBrgrKM8
  4. http://doctorskeptic.blogspot.com/2014/03/when-antivenoms-dont-work-you-gotta.html
  5. http://www.ncbi.nlm.nih.gov/pubmed/19570990
  6. http://www.ncbi.nlm.nih.gov/pubmed/19782716
  7. https://en.wikipedia.org/wiki/List_of_fatal_snake_bites_in_Australia
  8. http://www.australiangeographic.com.au/topics/wildlife/2013/03/australias-dangerous-animals-the-top-30/
  9. http://australianmuseum.net.au/spider-facts
  10. http://www.academia.edu/1163368/Antivenom_use_premedication_and_early_adverse_reactions_in_the_management_of_snake_bites_in_rural_Papua_New_Guinea
  11. https://www.mja.com.au/journal/2008/188/8/current-use-australian-snake-antivenoms-and-frequency-immediate-type
  12. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108466/
  13. https://uanews.arizona.edu/story/ua-scorpion-antivenom-collaboration-gains-fda-approval
  14. Complementary and alternative interventions in asthma, allergy, and immunology http://www.ncbi.nlm.nih.gov/pubmed/15330011
  15. Treatment of upper respiratory infections in primary care: A Randomized study using Aromatic herbs http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967840/
  16. The effects of peppermint on exercise performance http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607906/
  17. Phytotherapeutic and naturopathic adjuvant therapies in otorhinolaryngology  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259400/
  18. Application by either vapor inhalation or oral route provides benefit for both purulent and non-purulent respiratory problems, such as bronchitis, asthma, and chronic obstructive pulmonary disease (COPD).  http://www.ncbi.nlm.nih.gov/pubmed/20359267
  19. Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609378/
  20. Antispasmodic effect of Mentha piperita essential oil on tracheal smooth muscle of rats  http://www.ncbi.nlm.nih.gov/pubmed/20488237
  21. Inhibitors of ex vivo aggregation of human platelets induced by decompression, during reduced barometric pressure.  http://www.ncbi.nlm.nih.gov/pubmed/3715814
  22. Comparison of oral aspirin versus topical applied methyl salicylate for platelet inhibition  http://www.ncbi.nlm.nih.gov/pubmed/18698012
  23. Novel antiplatelet and antithrombotic activities of essential oil from Lavandula hybrida Reverchon “grosso”.  http://www.ncbi.nlm.nih.gov/pubmed/15636172
  24. Antithrombotic activity of clove oil.  http://www.ncbi.nlm.nih.gov/pubmed/8078176; http://snakebiteassist.co.za/venoms/cytotoxic-venom/
  25. Chemical Composition and Anti-Inflammatory, Cytotoxic and Antioxidant Activities of Essential Oil from Leaves of Mentha piperitaGrown in China http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262447/
  26. Anti-hemolytic and Anti-cytotoxicity Effect of Two ArtemisiaSpecies (A. campestris and A. herba-alba) Essential Oil against Snake Venom  http://www.fspublishers.org/Accepted_Papers/79967_..pdf
  27. Suppression of tumor necrosis factor-alpha-induced neutrophil adherence responses by essential oils, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781633/pdf/14668091.pdf
  28. Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664784/
  29. A near fatal case of high dose peppermint oil ingestion- Lessons learnt, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546250/
  30. Anti-inflammation effect of methyl salicylate 2-O-β-D-lactoside on adjuvant induced-arthritis rats, http://www.ncbi.nlm.nih.gov/pubmed/25637446
  31. http://www.nytimes.com/health/guides/poison/snake-bite-poison/overview.html
  32. Efficacy, safety, and use of snake antivenoms in the United States., http://www.ncbi.nlm.nih.gov/pubmed/11174237
  33. The effect of a single dose of prednisolone in dogs envenomated byVipera berus – a randomized, double-blind, placebo-controlled clinical trial
  34. Prevention and Treatment of Rattlesnake Bites in Dogs, http://www.animalmedcenter.com/news-and-press/article/prevention-and-treatment-of-rattlesnake-bites-in-dogs
  35. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207661/
  36. 08 RUCAVADO A., LOMONTE B. Neutralization of myonecrosis, hemorrhage, and edema induced by Bothrops asper snake venom by homologous and heterologous pre-existing antibodies in mice. Toxicon, 1996, 34, 567-77, http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000200011
St. Jude’s Miracle oilTM Got Pain? clinic

Posted on: July 11th, 2016 |

 

Got Pain? clinic lead speaker Chandra Vandry, RN covered chronic pain, insomnia, and new topics such as Got sight?, medical research regarding legal blindness and poor eyesight based on studies regarding Vitamin A deficiencies from medical studies.  In addition, a new topic on Got canine pain? covered canine arthritis, immunity, nutrition and Canine paralysis.  A video demo was displayed on a paraplegic dog that had regained its ability to walk, run and jump again based on light therapy, nutrition, detoxification and removal of cartilaginous tissues that cause paralysis or strokes in canines.

St. Jude’s Miracle oilTM July 9, 2016 Got Pain?, Got sight? and Got canine pain? expo

Posted on: July 1st, 2016 |

(more…)

St. Jude’s Miracle oilTM at ADC’s 2016 Health & Wellness Expo

Posted on: April 1st, 2016 |

 


ADC’s 2016 Health & Wellness Expo held at the North Austin Medical center had booths from businesses interested in community.  It was held between 11:30 am – 1:30 pm,Second Floor,    Classroom A & B.

 

St Jude’s Miracle Oil® test against Canine rash (Staphylococcal Dermatitis & Hypersensitivity in Dogs)

Posted on: March 8th, 2016 |

Samson and Delilah when they were puppies

By William Vandry

Contents

Staphylococcus

SJMO test on my dog with Staph Dermatitis

How is Staphylococcal hypersensitivity treated on dogs?

SJMO oils reference studies using same oils on Dog rashes, infections, parasites, mites, ticks, fleas

References

 

Staphylococcus

Staphylococcus is a name of a group of bacteria commonly found on the skin.  Dermatitis is a term that means inflammation of the skin.  This condition is also referred to as Staphylococcal pyoderma or Staph. pyoderma.  Pyoderma is a medical term for bacterial skin infection.

  • Staph infections are caused by staph bacteria that exist on the skin of many people and animals.
  • Staph bacteria lies dormant until the skin is irritated or the immune system is compromised.
  • Symptoms include lesions, itching, fever, pain, and loss of appetite.
  • Staph infections are usually treated with antibiotics, but the underlying cause must also be addressed.  In some cases, the infection may return after treatment is completed. This situation may be the result of an allergy to the staph bacteria, called Staphylococcus hypersensitivity or Staphylococcus allergy.

This is a different disease than a staph infection, and is characterized by recurrence. Because of this, treatment for staph hypersensitivity is usually long term and involves routine injections of the staph bacteria as a way to desensitize the pet’s immune system to the bacteria. Many pets respond well to desensitization therapy, but those that do not may require long term treatment with antibiotics as well as medicated baths.

Source: https://www.petcarerx.com/article/staph-infection-in-dogs-and-cats/2858

SJMO test on my dog with Staph Dermatitis

My dog Delilah had what most dogs get. They receive doggy rashes (Staphylococcal Dermatitis) on their stomach and ear areas among others.  I wipe her from head to paws each time she comes in, but at times there are bushes, plants or grass where they can still receive a reaction.  I applied topically a few drops of the Miracle oil product on her stomach area lightly around the rash.  The rash was not itching after a day.  The rash began to subside and was under control within 2 days.  We then applied it to her rash for 12 days, and these are photos of the first day and 12th:

Test 1

1. December 10, 2015 Delilah has staph or common dog rash

2. December 22, 2015 dog rash is gone, and as of February 9, 2016 it has not returned.

NOTE: The veterinary reference below is merely a reference to essential oils in studies.  Please consult your veterinarian and do not attempt to self treat or treat dogs.

12 days, no antibiotics, no cream, just sjmo applied 1-2x day.  (Not orally, and do not suggest your own trials, as essential oils can be toxic if consumed orally)  Usually a vet gives an antibiotic, and I have read in the veterinarian journals that there is no cure for staph or canine rash,  and you must keep maintaining the ointment up to two years.

My other dog Samson has a scrape on his paw that became aggravated when he played or ran. We applied a few drops of the SJMO directly on his paw scrape.

Test 2

  1. Samson’s paw due to scrape

2. Samson paw scape heals without scabbing two days later.

Test 3, Samson side scrape.

App. one day later wound has no scabbing, wound is bright pink, and even scab around fur in first photo showing darker fur has sloughed off.

Wound is totally healed within 5 days time.  Hair has grown back within app. 14 days.  Note dark spot is not former wound, it is a dark patch on skin.  Please read our wounds article for more information on SMO oils vs. wounds.

Test 4

Samson had also acquired the same rash as Delilah above, around same time.

Staph rash gone after SJMO application, same app. time as Delilah.

How is Staphylococcal hypersensitivity treated on dogs?

From: http://www.vcahospitals.com/main/pet-health-information/article/animal-health/staphylococcal-dermatitis-hypersensitivity-in-dogs/941

  1. “In hypersensitivity cases, long-term control is best achieved with periodic routine injections of Staphylococcal bacterin.”
  2. Treatment begins the same as for Staphylococcal dermatitis: oral antibiotics, medicated shampoos, and treatment to stop the itching.
  3. In hypersensitivity cases, long-term control is best achieved with periodic routine injections of Staphylococcal bacterin.
  4. After the initial series is completed, the injections are given subcutaneously (just below the skin) on an interval ranging from every three to four days to every two weeks.
  5. These injections frequently will give profound improvement when other treatments have failed.

How successful is this?

Desensitization therapy or “allergy shots” are rarely successful 100% of the time, in dogs or in people. Research has demonstrated that up to 77% of the dogs to respond well.

Most dogs will remain on routine injections for the first one to two years and then less frequent injections may be attempted.

What happens if Staphylococcal bacterin desensitization is not successful?

The dog will require periodic treatment with antibiotics and medicated baths.

This is not the most desirable approach because Staphylococcus will often develop resistance to the antibiotics.

If this occurs, a change in the specific antibiotic used will be necessary. This will also involve more bacteriological tests and antibiotic sensitivity testing in order to establish another appropriate course of treatment.

SJMO oils reference studies using same oils on Dog rashes, infections, parasites, mites, ticks, fleas

Upon researching essential oils that are also in our product, what do the medical journals say?  Is there any scientific research to gear for future clinical trials on a more formal level than tests?  The ever watchful FDA has a purpose.  There are many claims of new cures, or product sales more than actual research.  There is a valid reason the FDA regulates quick cures, or products we know take advantage of those concerned medically.   We do not do that.  We do not make claims of cures, or anything that prescribes medicine.  More research is needed, and we always look forward to future clinical trials.  Let’s look at what the very hard to find trials have shown success with staph or bacteria, viruses, etc. Below are medical journals from NCBI and PubMed medical journals specifically correlating essential oils effect on above viruses, strains, etc.  Our research is comparing the oils specifically from St. Jude’s Miracle oilTM (peppermint, eucalyptus, lavender, geranium, clary sage, clove bud, myrrh, and frankincense and wintergreen) and effect on viruses, MDR, MSSA, MRSA,  bacteria, staph and others.

Eucalyptus
Research has shown eucalyptus oil used as herbal gel has had a therapeutic efficacy on skin rashes for dogs1.
Eucalyptus oil has Anti-nociceptive (lower pain stimuli) and anti-inflammatory effects2.
Ectoparasites (fleas and other skin parasites) in dogs) can be transmitted dog to dog, trees, environment. General treatments such as Flea collars, shampoos and powders are not suggested as in the past. Lice generally has spot on treatments similar to flea treatment and is generally a 4-8 week time, including treatment of house, cars, etc.. Ticks should be removed properly and if removed with jaw area still intact, the tick can regurgitates blood possibly causing infection. Mites are spot on treated, or medicinal shampoos.3
Another application that may be of interest to livestock producers is as a treatment for ectoparasites and non-specific skin infections. Two experimental herbal mixtures (AV/EPP/14 and AV/AAGD/14 produced by Dabur Ayurvet Limited in India), which contain Eucalyptus globulus oil along with several other plant oils, have been tested on dogs to treat ectoparasites, fungal skin infections, and non-specific skin infections. While the mixtures appear to be effective, no comparative treatments were used in the studies. (Agrawal 1997 and Bhilegaonkar and Maske 1997).4
And acaricidal effect of Pelargonium roseum and Eucalyptus globulus essential oils against adult stage of Rhipicephalus (Brown tick), immersion in a 5% solution.%.5
Data is from research studies on essential oils and ectoparasites.6
Eucalyptus antibacterial effect against multidrug-resistant (MDR) bacteria.7
Antibacterial effect of essential oils from two medicinal plants against Methicillin-resistant Staphylococcus aureus (MRSA).8

Geranium
Gentle and safe, antifungal. Good for skin irritations, fungal ear infections. Effective in repelling ticks.1
In vitro contact assays using the dog ear mite, Otodectes cynotis (Hering) (Astigmata: Psoroptidae), found that the essential oil constituent, geraniol, killed all mites within 1 h at concentrations of ≥5% (v/v). (NOTE: Geraniol is a monoterpenoid and an alcohol that occurs in small quantities in geranium).2
Engorged adults of Rhipacephalus spp. immersed in 5% essential oil of geranium (Pelargonium roseum) (Pirali-Kheirabadi et al., 2009) were found to have mortalities of 79.2% after 24 h and 83.3% after 48 h, respectively, and a significant decrease in the egg mass laid by female Rhipicephalus was observed after immersion in the essential oils of geranium (Pirali- Kheirabadi et al., 2009).3
Studies show Geranium antimicrobial susceptibility of Staphylococcus pseudintermedius from dogs.4.
Patchouli, tea tree, geranium, lavender essential oils and Citricidal (grapefruit seed extract) anti-bacterial activity.5
Antimicrobial activity of geranium oil against clinical strains of Staphylococcus aureus.6

Clove
Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species.1

Lavender
Lavender effect against MSSA and MRSA.1
Lavender against antibiotic-restistant bacteria.2
Lavender oil, petigrain oil, clary sage oil, ylang ylang oil and jasmine combination against Staph.3

Myrrh
Black pepper, cananga, and myrrh oils have potential against Staphylococcus aureus.1
Myrrh antibacterial, antifungal activity against pathogenic strains E coli, Staph, Pseudomonas and Candida.2

Frankincense
Frankincense (Boswellia serrata) effective against Staphylococcus.1

Wintergreen
Wintergreen acts as an anti-inflammatory and antimicrobial agent.1

Peppermint

(Including Eucalyptus, Lavender, Clove Bud, Peppermint) effective antiseptic topical , Lavender, Clove Bud, PeppermintAtta, A.H. and A. Alkofahi. 1998. Anti-notreatment for MRSA and antimycotic-resistant Candida species.1

The battle against multi-resistant strains: Renaissance of antimicrobial essential oils as a promising force to fight hospital-acquired infections.2

 

William Vandry

 

References

Eucalyptus

1.Atta, A.H. and A. Alkofahi. 1998.                                                                                                                                                                                                            2.Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. Journal of Ethnopharmacology, 60 (2): 117-124.  (http://www.ncbi.nlm.nih.gov/pubmed/9582001)
3.http://www.willows.uk.net/general-practice-service/pet-health-information/ectoparasites-in-dogs
4.Bhilegaonkar, N.G. and D.K. Maske. 1997. Efficacy of a herbal compound AV/EPP/14 against ectoparasites of dogs.  Indian Veterinary Journal, 74 (10): 869-870 http://www.ansci.cornell.edu/plants/medicinal/eucalyp.html
5.Pirali-Kheirabadi, K., Razzaghi-Abyaneh, M. & Halajian, A. (2009) Acaricidal effect of Pelargonium roseum and Eucalyptus globulus essential oils against adult stage of Rhipicephalus (Boophilus) annulatus in vitro. Veterinary Parasitology, 162, 346–349. 6.http://onlinelibrary.wiley.com/doi/10.1111/mve.12033/pdf From research studies on essential oils and ectoparasites.
7.http://www.ncbi.nlm.nih.gov/pubmed/21591991
8.http://www.ncbi.nlm.nih.gov/pubmed/19576738

Geranium

1.http://www.natural-dog-health-remedies.com/essential-oils-for-dogs.html
2.Perrucci, S., Cioni, P.L., Flamini, G., Morelli, I. & Macchioni, G. (1994) Acaricidal agents of natural origin against Psoroptes cuniculi . Parassitologia (Rome), 36, 269–271. Perrucci, S., Macchioni, G., Cioni, P.C., Flamini, G., Morelli, I. & Taccini, F. (1996) The activity of volatile compounds from Lavandula angustifolia against Psoraptes cuniculi . Phytotherapy Research, 10, 5–8.
3.Pirali-Kheirabadi, K., Razzaghi-Abyaneh, M. & Halajian, A. (2009) Acaricidal effect of Pelargonium roseum and Eucalyptus globulus essential oils against adult stage of Rhipicephalus (Boophilus) annulatus in vitro. Veterinary Parasitology, 162, 346–349.
4.In vitro evaluation of topical biocide and antimicrobial susceptibility of Staphylococcus pseudintermedius from dogs (Geranium safe), 1Departments of Clinical Studies and Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada Valentine BK1, Dew W, Yu A, Weese JS.  http://www.ncbi.nlm.nih.gov/pubmed/?term=geranium+oil+canine+dogs
5.http://www.ncbi.nlm.nih.gov/pubmed/15555788
6.http://www.ncbi.nlm.nih.gov/pubmed/?term=8.+Antimicrobial+activity+of+geranium+oil+against+clinical+strains+of+Staphylococcus+aureus

Clove

1.http://www.ncbi.nlm.nih.gov/pubmed/?term=Antifungal+activity+of+the+clove+essential+oil+from+aromaticum+on+Candida%2C+Aspergillus+and+dermatophyte+species+Euge%C2%B4+nia+Pinto%2C1+Lu%C4%B1%C2%B4s+Vale-Silva%2C1+Carlos+Cavaleiro2+and+L%C4%B1%C2%B4gia+Salgueiro2

Lavender

1.http://www.ncbi.nlm.nih.gov/pubmed/19249919
2.http://www.ncbi.nlm.nih.gov/pubmed/25174508                                                                                                                                                                                   3.http://www.ncbi.nlm.nih.gov/pubmed/?term=lavender+oil%2C+petigrain+oil%2C+clary+sage+oil%2C+ylang+ylang+oil+and+jasmine+combination+against+Staph

Myrrh

1.http://www.ncbi.nlm.nih.gov/pubmed/?term=Black+pepper%2C+cananga2C+and+myrrh+oils+have+potential+against++Staphylococcus+aureus
2.http://www.ncbi.nlm.nih.gov/pubmed/10865454

Frankincense

1.http://www.ncbi.nlm.nih.gov/pubmed/?term=Frankincense+(Boswellia+serrata)+effective+against+Staphylococcus

Wintergreen

1.http://www.ncbi.nlm.nih.gov/pubmed/21555977

Peppermint

1.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957173/Essential oils Eucalyptus, Lavender, Clove Bud, Peppermint
2.http://www.ncbi.nlm.nih.gov/pubmed/19473851

 

 

Essential oils research on wounds, burns

Posted on: February 2nd, 2016 |

Disclaimer: Information within this site is for educational purposes only. The U.S. Food & Drug Administration has not evaluated statements about the product efficacy. These products are not intended to diagnose, treat, cure, or prevent any disease.  Consult your physician before using for advice.

Content

1, Burns and Wounds

2. Medical journals essential oils wounds and burns

3. SJMO wound tests

4. Medical references

1. Burns and Wounds

From the website on hospitals and burns, here is a chart to define burns.1

From the same website, here are photos of burn wounds in the first, second and third degree.  Burn injury is the destruction of the layers of the skin and associated structures.  Burn injury is the destruction of the layers of the skin and associated structures.

What exactly is the healing time for wounds or burns?  From sharecare, Dr. Stuard A. Linder, MD (Plastic surgery) defines healing time:

“…Length of healing time for burning wounds to heal depends on the depth and extend of the wound.  First-degree burns heal quite quickly in usually less than 3 weeks.  Deep second-degree and third-degree burns may require debridement, antibiotic dressing change, and surgical reconstruction with skin grafts or flaps requiring months of healing and rehabilitation.  Larger 2nd and 3rd degree burns over 90% fo total body surface area may be fatal if not aggressively treated soon after the incident..”2

All open wounds are contaminated with bacteria, sometimes leading to wound infection which is a scourge to patients and caregivers, with some estimates as high as 30% of wounds affected.3

Development of wound treatment methods were developed in 2001 at the bedside, primarily to provide pain relief in dying patients with painful pressure ulcers. At that time there were no guidelines for palliative wound care, and wound healing was seen as an unrealistic goal of treatment in this patient population.4

What are general pain methods?  Studies using lidocaine for burns showed it was safe for topical use on a wound, as long as it is below toxicity level.  Nothing in the literature was found to either support or contradict use of lidocaine in the wound bed for pain relief, yet it is known that topical lidocaine can decrease pain.5

2. Medical journals reference to essential oils wounds and burns

Regarding wounds, I researched our oils in the St. Jude’s Miracle oilTM product, and compared them with medical journals on potential EO may have on wounds or burns.  What does the NCBI or Pubmed state oils we also have in our product do?  Here are medical references regarding the some of the same oils in or product.

Wintergreen

Oil of wintergreen has a strong and cooling aroma, and it contains 85%-99% methyl salicylate which is aspirin-like and can contribute to pain relief as promoted in commercial literature.7

Peppermint

Antibacterial and antifungal properties of essential oils.  Essential oils of spices and herbs (thyme, origanum, mint, cinnamon, salvia and clove) were found to possess the strongest antimicrobial properties among many tested.8

Myrrh

Effect of myrrh (Commiphora molmol) on leukocyte levels before and during healing from gastric ulcer or skin injury.  Myrrh (Commiphora molmol) has been widely used as an anti-inflammatory and wound healing commercial product.9

This complimentary study also discusses the use of myrrh in wound management.10

Myrrh oil has anti-inflammatory and analgesic activity in wound management.11

Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha.12

Frankincense

In addition to anti-inflammatory effects, Frankincense has been shown to have wound healing, antiulcer, and anti-diarrheal properties.13

Frankincense was used for symptomatic knee osteoarthritis.14

Lavender

From PubMed, this paper reports on a literature review of evidence on the influence of essential oils on wound healing and their potential application in clinical practice. It focuses mainly on tea tree, lavender, chamomile, thyme and ocimum oils.15

Among the PubMed claims made for lavender oil are that is it antibacterial, antifungal, carminative (smooth muscle relaxing), sedative, antidepressive and effective for burns and insect bites.16

This study on PubMed compared the effects of transcutaneous electrical nerve stimulation (TENS), saline solution (SS), povidone-iodine (PI), and lavender oil (Lavandula angustifolia) through expression of growth factors in a rat model of wound healing.  Wound closure progressed more rapidly in the TENS and lavender oil groups than in the control and other study groups.17 

A natural polymeric composite films made of essential oils (EOs) dispersed in sodium alginate (NaAlg) matrix, with remarkable anti-microbial and anti-fungal properties. Namely, elicriso italic, chamomile blue, cinnamon, lavender, tea tree, peppermint, eucalyptus, lemongrass and lemon oils were encapsulated in the films as potential active substances.18  

Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels.  These properties are similar to those recently reported for Mo. The anti-agitation effects in patients and the depressant effects of La we report in neural membranes in-vitro are unlikely to reflect a sedative interaction with any of the ionotropic receptors examined here. These data suggest that components common to the two oils are worthy of focus to identify the actives underlying the neuronal depressant and anti-agitation activities reported.19

Healing advantages of lavender essential oil during episiotomy recovery: a clinical trial.  This study suggests application of lavender essential oil instead of povidone-iodine for episiotomy wound care.20 

The antimicrobial activity of high-necrodane and other lavender oils on methicillin-sensitive and -resistant Staphylococcus aureus (MSSA and MRSA).21

Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels.22

Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill.23

Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial.  Essential oils blended with lavender (Lavandula officinalis), clary sage (Salvia sclarea) and marjoram (Origanum majorana) in a 2:1:1 ratio was diluted in unscented cream at 3% concentration for the essential oil group. All outpatients used the cream daily to massage their lower abdomen from the end of the last menstruation continuing to the beginning of the next menstruation.24

Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea.  Essential oils blended with lavender (Lavandula officinalis), clary sage (Salvia sclarea) and marjoram (Origanum majorana) in a 2:1:1 ratio was diluted in unscented cream at 3% concentration for the essential oil group. All outpatients used the cream daily to massage their lower abdomen from the end of the last menstruation continuing to the beginning of the next menstruation.25

Geranium oil

In this study the tested geranium oil was efficacious against Gram-negative pathogens responsible for problems with wound treatment. The results suggest that geranium oil may be considered an effective component of therapy in the case of frequent recurrences of infections caused by resistant pathogens.26 

The effect of essential oils on methicillin-resistant Staphylococcus aureus using a dressing model.  A combination of Citricidal and geranium oil showed the greatest-anti-bacterial effects against MRSA, whilst a combination of geranium and tea tree oil was most active against the methicillin-sensitive S. aureus (Oxford strain). This study demonstrates the potential of essential oils and essential oil vapours as antibacterial agents and for use in the treatment of MRSA infection.27

Geranium has shown temporary relief of neuralgia pain.28

Antibacterial activity of geranium oil against Gram-negative bacteria isolated from difficult-to-heal wounds.29

Clary sage

Clary sage oil may be applied to treat wounds and skin infection.30

Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial.  Essential oils blended with lavender (Lavandula officinalis), clary sage (Salvia sclarea) and marjoram (Origanum majorana) in a 2:1:1 ratio was diluted in unscented cream at 3% concentration for the essential oil group. All outpatients used the cream daily to massage their lower abdomen from the end of the last menstruation continuing to the beginning of the next menstruation.31

Clove

Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species.32

Antibacterial and antifungal properties of essential oils.33 

Eucalyptus

The Phytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats.34

Antibacterial activity of the essential oils from the leaves of Eucalyptus globulus against Escherichia coli and Staphylococcus aureus35

3. SJMO wound tests

Before I start, a few things on evidence.  Anecdotal trials can be a testimony, a hearsay statement or a claim without backing.  Wikepedia defines Anecdotal evidence as considered dubious support of a generalized claim; it is, however, within the scope of scientific method for claims regarding particular instances, for example the use of case studies in medicine.

Scientific method (https://en.wikipedia.org/wiki/Scientific_method)

Wikipedia defines SM as:

  1. general, the strongest tests of hypotheses come from carefully controlled and replicated experiments that gather empirical data.
  2. If a particular hypothesis becomes very well supported a general theory may be developed.
  3. Although procedures vary from one field of inquiry to another, identifiable features are frequently shared in common between them.
  4. The overall process of the scientific method involves making conjectures (hypotheses), deriving predictions from them as logical consequences, and then carrying out experiments based on those predictions.
  5. A hypothesis is a conjecture, based on knowledge obtained while formulating the question.
  6. The hypothesis might be very specific or it might be broad. Scientists then test hypotheses by conducting experiments.
  7. Under modern interpretations, a scientific hypothesis must be falsifiable, implying that it is possible to identify a possible outcome of an experiment that conflicts with predictions deduced from the hypothesis; otherwise, the hypothesis cannot be meaningfully tested.
  8. The purpose of an experiment is to determine whether observations agree with or conflict with the predictions derived from a hypothesis.

Below are some interesting tests regarding the Miracle oil product.  We have received photos, testimonies, along with general information on the cause and effect regarding using the oil with wounds.  These are just tests, for more clinical trials on essential oils please reference the journals below to different research.

Test 1 on wounds

These photos show a wound that were observed in 2014, and Miracle oil was applied around wound, and photos are from a 32 hour timeline.

Photo 1 of wound was taken July 7, 2014 at 12:08pm

Photo 2 of wound was taken July 08, 2014 5:57 AM

Photo 3 of wound was taken July 8, 2014 at 7:55pm

sjmo after9sjmo after6sjmo after2

These photos show a wound that was observed, and Miracle oil was applied around wound, and photos are from a 32 hour timeline.  Below are photos of a an abrasion from wikipedia, which has nothing to do with this product or our research, it is simply an independent comparison on a similar wound.  You can see the normal time for abrasions take quite a while, and even after 14 days, the wound below from wikipedia is still not healed after. (https://en.wikipedia.org/wiki/Abrasion_(medical)

        

Photo 1, 32 minutes after injury, Photo 2 day, 19 hours after injury, Phoro 3 14 days after injury.

SJMO test shows after after 32 hours, wound is not bleeding, sealed, and healing.

Wound comparison from Wikipedia show 14 DAYS, wound has not healed, and is still clearly inflamed, even showing bright redness around wound.

Test 2 on wounds

Here my student Mauricio obtained a black eye.  The hematoma is clear, yet we applied the oil.  22 hours and 22 minutes later, the hematoma is gone.  You can also compare the authenticity of the photo noticing the black eye is still fresh and dark, and has not faded out to a lighter color when healed after a week or so.  Standard RICE therapy for 7-10 days is the usual therapy.  What is the standard therapy and healing time according to WebMD?

“…Besides icy treatment, there’s not much that can be done for a black eye except avoid doing anything that could cause further injury, such as putting pressure on the swollen eye or trying to force it open. If you need a pain reliever, take aspirin or acetaminophen…” (Tylenol)  – WebMD

Photo 1, 1 9:17pm May 19, 2015

Photo 2, 6:55pm May 20, 2015

Mauricioeye1  mauricioeye4

Test 3 on wounds

The two photos below are an eye wound.  The clear tear in the eyelid area needed a few stitches.  If you ever have any wound, please see your physician or ER immediately.  Do not use our models for reference as a means of treating yourself. The oil was applied around the wound for five days.  After approximately 45 minutes, the wound stopped bleeding and began to seal.

Day one                                                        Day five

Test 4 on wounds

I had one of my children’s parents contact me.  Her son had burned his leg on a motorcycle and had an impressive deep 2nd degree burn.  She notified me that her Medical Doctor was concerned and stated he was to be without any activity for almost two months.  I have a copy of the doctor’s letter, and antibiotics and gauze changing were a mandatory requirement.  If it were to be infected, an immediate visit to a local ER or appointment was required to not allow the infection to spread.  She used the oil and within a day the pain was reduced and within three days it was very manageable.  In 10 days she posted photos on our facebook page which showed impressive results.  Her final post shows day one, day 10 and day 20, which you can barely even see there was a burn.  I would like more clinical trials, and perhaps we can do more to explore the effects of the oils.

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You can read the parent’s post on our facebook page:

https://www.facebook.com/photo.php?fbid=1505322029774466&set=gm.952901314789768&type=3&theater

Upon researching essential oils that are also in our product, what do the medical journals say?  Is there any scientific research to gear for future clinical trials on a more formal level than tests?  The ever watchful FDA has a purpose.  There are many claims of new cures, or product sales more than research.  There is a valid reason the FDA regulates quick cures, or what we know take advantage of those concerned medically.   We do not do that.  We do not make claims of cures, or anything that prescribes medicine.  More research is needed, and we always look forward to future clinical trials.  More formal research and trials we aspire for.

William Vandry

4. Medical references

  1. http://hospitals.unm.edu/burn/classification.shtml
  2. https://www.sharecare.com/health/skin-burn-treatment/how-long-take-burn-heal
  3. Lindholm C. Pressure Ulcers and Infection-Understanding Clinical Features. Ostomy Wound Manage. 2003;49(5): 4-7. – See more at: http://www.woundsresearch.com/article/palliative-wound-treatment-promotes-healing#sthash.gcCu3Nsi.dpuf
  4. Rinne C. Laying the foundation: the multidisciplinary approach to program development. Paper presented at: Southwest Missouri State University, Four-Day Wound Management Workshop; September 2001; Warrensburg, MO. – See more at: http://www.woundsresearch.com/article/palliative-wound-treatment-promotes-healing#sthash.gcCu3Nsi.dpuf
  5. Christensen T, Thorum T, Kubiak E. Lidocaine analgesia for removal of wound vacuum-assisted closure dressings: a randomized double-blinded placebo-controlled trial. J Orthop Trauma. 27(2):107-112 – See more at: http://www.woundsresearch.com/article/palliative-wound-treatment-promotes-healing#sthash.gcCu3Nsi.dpuf
  6. Mathieu et al., 2006; Menke et al., 2007
  7. Wintergreen essential oil same as birch? www.experience-essential-oils.com/wintergreen-essential-oil.html. – See more at: http://www.woundsresearch.com/article/palliative-wound-treatment-promotes-healing#sthash.gcCu3Nsi.dpuf
  8. Curr Med Chem. 2003 May;10(10):813-29.Antibacterial and antifungal properties of essential oils.  Kalemba D, Kunicka A.SourceInstitute of General Food Chemistry, Technical University of Lodz, Poland.
  9. Effect of myrrh (Commiphora molmol) on leukocyte levels before and during healing from gastric ulcer or skin injury http://www.ncbi.nlm.nih.gov/pubmed/19995243
  10. Integrating complementary and alternative medicine: use of myrrh in wound managementWalsh ME 1, Reis D, Jones T. http://www.ncbi.nlm.nih.gov/pubmed/20709267
  11. Analgesic, anti-inflammatory and anti-hyperlipidemic activities of Commiphora molmol extract (Myrrh), http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4576796/

Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha.  http://www.ncbi.nlm.nih.gov/pubmed/21167270

  1. Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha.  Source: Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing 210046, PR China.,
  2. A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. World J Gastroenterol. 2010;16:4504–14. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924999/
  3. Chopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A, Narsimulu G, et al. Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: A randomized, double-blind, controlled equivalence drug trial. Rheumatology (Oxford) 2013;52:1408–17.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175880/
  4. The influence of essential oils on the process of wound healing: a review of the current evidence http://www.ncbi.nlm.nih.gov/pubmed/17722522
  5. Biological activities of lavender essential oil. http://www.ncbi.nlm.nih.gov/pubmed/12112282
  6. A Comparison Study of Growth Factor Expression following Treatment with Transcutaneous Electrical Nerve Stimulation, Saline Solution, Povidone-Iodine, and Lavender Oil in Wounds Healing http://www.ncbi.nlm.nih.gov/pubmed/23861704
  7. All-natural composite wound dressing films of essential oils encapsulated in sodium alginate with antimicrobial properties. http://www.ncbi.nlm.nih.gov/pubmed/24211443
  8. http://www.ncbi.nlm.nih.gov/pubmed/18957173
  9. http://www.ncbi.nlm.nih.gov/pubmed/21168115
  10. The antimicrobial activity of high-necrodane and other lavender oils on methicillin-sensitive and -resistant Staphylococcus aureus (MSSA and MRSA). http://www.ncbi.nlm.nih.gov/pubmed/19249919
  11. Pharmacological profile of essential oils derived from Lavandula angustifolia and Melissa officinalis with anti-agitation properties: focus on ligand-gated channels.  http://www.ncbi.nlm.nih.gov/pubmed/18957173
  12. Hajhashemi, V., Ghannadi, A., & Sharif, B. (2003). Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of lavandula angustifolia mill. Journal of Ethnopharmacology, 89(1), 67-71.(Lavender), http://www.sciencedirect.com/science/article/pii/S0378874103002344
  13. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial.  http://www.ncbi.nlm.nih.gov/pubmed/22435409
  14. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial.  Ou MC, Hsu TF, Lai AC, Lin YT, Lin CC.  SourceDepartment of Applied Cosmetology, Hungkuang University, Taichung, Taiwan. [email protected], http://www.ncbi.nlm.nih.gov/pubmed/?term=Pain+relief+assessment+by+aromatic+essential+oil+massage+on+outpatients+with+primary+dysmenorrhe
  15. The antibacterial activity of geranium oil against Gram-negative bacteria isolated from difficult-to-heal wounds  http://www.ncbi.nlm.nih.gov/pubmed/24290961
  16. http://www.ncbi.nlm.nih.gov/pubmed/15555788
  17. Greenway, f, Frome & Engels, T. (2003). Temporary relief of postherpetic neuralgia pain with topical geranium oil. American J of Medicine, 115, 586-587.
  18. The antibacterial activity of geranium oil against Gram-negative bacteria isolated from difficult-to-heal wounds.  http://www.ncbi.nlm.nih.gov/pubmed/24290961
  19. The effect of clarysageoil on staphylococci responsible for wound infections.  http://www.ncbi.nlm.nih.gov/pubmed/?term=Wounds+clary+sage+oil
  20. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial.  http://www.ncbi.nlm.nih.gov/pubmed/22435409
  21. Antifungal activity of the clove essential oil from aromaticum on Candida, Aspergillus and dermatophyte species Euge´ nia Pinto,1 Luı´s Vale-Silva,1 Carlos Cavaleiro2 and Lı´gia Salgueiro2, http://www.ncbi.nlm.nih.gov/pubmed/19589904
  22. SAA no. 8
  23. Phytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats.  Gbenou JD, Ahounou JF, Akakpo HB, Laleye A, Yayi E, Gbaguidi F, Baba-Moussa L, Darboux R, Dansou P, Moudachirou M, Kotchoni SO.  SourceLaboratoire de Pharmacognosie et des Huiles Essentielles, Faculté des Sciences de la Santé, Faculté des Sciences et Techniques, Université d’Abomey Calavi, 01 BP 918, Cotonou, Benin. http://www.ncbi.nlm.nih.gov/pubmed/?term=ical+composition+of+Cymbopogon+citratus+and+Eucalyptus+citriodora+essential+oils+and+their+anti-inflammator
  24. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609378
  25. Agrawal, A.K. 1997. Therapeutic efficacy of a herbal gel for skin affections in dogs. Indian Veterinary Journal, 74 (5): 417-419.

Further research into the efficacy, safety, optimal uses, and standardization of herbal remedies is clearly needed. Inhibiting factors in the United States include the nonpatentability of herbal materials in a system in which the typical costs of double-blind testing for Food and Drug Administration (FDA) approval of drugs range in the millions of dollars, requiring patentability for private enterprises to attain a profit. Since herbal remedies currently remain in the category of dietary supplements, a different mechanism of funding for research is needed. The funding for complementary and alternative medicines research provided through the National Institutes of Health is meager compared with private and public funding of research for conventional drugs.

Got Pain? You better read this!

Posted on: February 2nd, 2016 |

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Disclaimer: Information within this site is for educational purposes only. The U.S. Food & Drug Administration has not evaluated statements about the product efficacy. These products are not intended to diagnose, treat, cure, or prevent any disease.  Consult your physician before using for advice.

Pain has many identities.  Some have joint pain, or migraines, and there are past articles on those.  See:

http://www.williamvandry.com/2013/04/28/professor-vandrys-view-again-the-racehorse-theory-for-joints-collagen-1-2-and-3-vitamins-and-minerals-for-the-joints-serrazyme-nattokinese-fibrinogen-breakup-lumen-90-and-of-course/

Different pains in this article are Chronic pain, and specifically Neurological pain, or Neuropathy and Spinal paralysis.  I have Jiu-jitsu students or friends over the years due to pinched nerves, injuries and other causes develop neuropathy.  I found a research journal on essential oils and neuropathy.  Most of you reading this already know this, but for those that don’t, my wife and I invented the product St. Jude’s Miracle oil TM.  The product is a proprietary trade secret of 9 essential oils originally designed to relieve pain for athletes.  I have seen Neurological pain with new students, and new clients with pre-existing neuropathy.  Let’s break down a few points on pain.

Source: Dawn Langley-Brady RN, MSN, CHPN, Advanced Graduate Paper for The East West School of Herbal and Aromatic Studies

(http://theida.com/ew/wp-content/uploads/2010/10/Neuropathies-Essential-oils-show-promising-results-in-the-fight-against-symptoms.pdf):

Chronic pain

Chronic pain affects 1.5 billion people worldwide with 116 million of those people residing in the United States of America.1

Pain is divided into two categories:

Nociceptive pain, which includes visceral and somatic pain.

Neuropathic pain.

Of those 116 million people suffering from chronic pain, approximately four million people in the United States of America are currently suffering from neuropathic pain.2

Neuropathic pain is defined as a pain caused by a lesion or disease of the somatosensory nervous system and can be further divided into central and peripheral neuropathic pain.3

Causes

According to the National Institute of Neurological Disorders and Stroke (neuropathic pain is caused by physical trauma or injury, systemic diseases, autoimmune disorders, infections and can be inherited (NINDS, 2011).4

Systemic diseases causing neuropathic pain include: Renal disease, heart and respiratory disease, endocrine diseases such as diabetes metabolic disorders, hormonal imbalances, toxins, connective tissue and inflammatory disorders, alcoholism, vitamin deficiencies, tumors (malignant and benign) and repetitive stress.

Infections causing neuropathic pain include: Human immunodeficiency virus, herpes varicellazoster, herpes simplex virus, cytomegalovirus, Epstein-Barr virus, Lyme disease, diphtheria, leprosy and bacterial and viral infections.

Some neuropathies are caused by inflammation resulting from immune system disorders include:

Fibromyalgia, multiple sclerosis, Guillain-Barre Syndrome, or acute inflammatory demyelinating neuropathy, chronic inflammatory demyelinating neuropathy, trigeminal neuralgia and multifocal motor neuropathy. Neuropathic pain can also be caused by a hereditary genetic abnormality, genetic mutations or by no known cause (idiopathic).

Current Treatment

The Cleveland Clinic describes neuropathic pain and treatments:

Tricyclic antidepressants or over the counter pain relievers, and anticonvulsants

Serotonin-norepinephrine reuptake inhibitors such as Cymbalta and Effexor XR.

When those no longer work, opiates are prescribed. Opiates often used are Oxycontin, Oxycodone, Morphine Sulfate.

Alternatives less used are: TENS unit, acupuncture, aromatherapy, biofeedback, hand and foot baths, diet therapy, exercise, guided imagery, herbal remedies, infrared light therapy, massage, physical therapy, reflexology, Reiki, Yoga and more.5

Many Jiu-jitsu practitioners, athletes or general public generally have neck pain, usually in the cervical disk area, and a lot of those are rolling off your necks during the years of training, and of course those are also related to malnutrition where the collagen levels in the disks degenerate.

I know so many fellow black belts that develop tingling, or nerve pain, chronic tightness in the neck or shoulder areas among others.  Langley-Brady’s research shows different essential oils used, but I will specify more in the direction of the oils in our Miracle oil product specifically for Neuropathy/neuralgia and medical research in the ncbi or pubmed.

Research on Mentha piperita (Peppermint oil)

Peppermint oil has shown anti-nociceptive effects (reducing sensitivity to painful stimuli) against induced writhing and thermal stimulation in laboratory rats as well as anti-inflammatory properties for induced ear edema and granulomas in study rats.6

Menthol, the primary alcohol in Mentha x piperita, is the active ingredient in the over the counter product Eucalyptamint.  A research study on Eucalyptamint, was conducted in 1991 and found up to four times an increase in cutaneous blood flow and skin and muscle temperatures along with diminished pain at the site of application which lasted upwards of forty-five minutes.7

Research on Pelargonium x asperum (Geranium oil)

A research study of an over the counter homeopathic remedy approved by the United States Food and Drug Administration (FDA), Neuragen PN, showed a reduction of at least fifty percent of pain reported by fifty-six percent of those study participants diagnosed with diabetic peripheral neuropathy (“Neuragen PN,” 2010, p. 5).

Neuragen PN contains a blend of six homeopathic substances and five essential oils.  The five oils used are:

Geranium oil, Lavender oil, Bergamot oil, tea tree oil, and eucalyptus oil.8

In 2006, a Japanese research study show the effectiveness of geranium essential oil on both acute and chronic inflammatory processes, significant reduction of inflammation and prevention of arthritis was found.9

A Korean study in 2011 using an aromatherapy blend with massage for pain relief of menstrual cramping. The study used a five percent dilution of the essential oils of cinnamon, clary sage, geranium, ginger and marjoram in a base of almond oil. The study group showed great reduction in pain without re-dosing unlike the needed re-dosing of the control group participants who received acetaminophen.10

Dr. Jane Buckle, PhD. recommends, amongst many, the use of essential oils of Piper nigrum, Mentha x piperita (Peppermint oil) and Rosmarinus officinalis and for children – Pelargonium graveolens.11

Mentha x piperita (Peppermint oil) for analgesic use for headaches and a blend of Pelargonium graveolens, Citrus limon and Juniperus communis for an allover massage oil for pain.12

Jade Shutes recommends blends with any of the following oils for pain reduction in patients with Fibromyalgia: Piper nigrum, Betula lenta, Matricaria recutita, Chamaemelum nobile, Metha x piperita (Peppermint oil), Rosmarinus officinalis and more.13

Valerie Ann Worwood recommends Lavendula agustifolia (Lavender), Chamaemelum nobile, Eugenia carophyllata (Clove bud) and Mentha x piperita (Peppermint oil) for neuralgia.14

In August 2006, studies found Mentha x piperita (Peppermint oil) to have analgesic and anesthetic effects on the central and peripheral nervous systems as well as relaxing the gastrointestinal tract and having anti-tumoral, antiviral and antibacterial properties.15

In 2010, Iranian researchers found Mentha x piperita (Peppermint oil) to be effective against E. Coli, S. aureus, Pseudomonas aeruginose, S. faecalis and Klebsiella pneumonia in addition to being a potent anti-oxidant and cytotoxic to the human tumor cell line.16

Geranium essential oil is widely prized generally for its astringent, hemostatic, diuretic, antiseptic, antidepressant, tonic, antibiotic, anti-spasmodic, and anti-infectious properties and its overall balancing effect.17

Geranium essential oil can be beneficial to individuals suffering from nerve pain (neuropathy) where it is applied on the skin directly to relieve the pain, particularly that associated with shingles, a viral disease known for its painful blistering skin rash.18

In addition, because of the anti-neuroinflammatory effects of Geranium essential oil on microglial cells and hence its potential benefits in the prevention or treatment of neurodegenerative diseases where neuroinflammation is part of the pathophysiology, geranium essential oil has steadily gained the interest of the research community and medical profession.19

In the study of Pattnaik, Subramanyam, and Kole (1996), geranium essential oil was harmful to twelve bacterial strains out of the twenty-two bacteria evaluated, including Grampositive cocci and rods and Gram-negative rods, and was inhibitory against twelve fungi.20

The anti-inflammatory and antimicrobial effects of geranium essential oil altogether present treatment to individuals with diseases of bacterial or inflammatory etiology.

For instance, geranium essential oil (Geranium robertianum) in conjunction with essential oils from clove (Syzygium aromaticum) and lavender (Lavandula angustifolia) can diminish the symptoms of acute external otitis (viz., tenderness, itching, redness, edema, and discharge) with proven efficacy that is even equal to ciprofloxacin, an antibiotic.21

I have found research regarding pain, and PTSD that was quoted in a past article on the SJMO website:

Aromatherapy has major effects on decreasing pain and depression levels, and can be a useful nursing intervention for arthritis patients.  The essential oils used were lavender, marjoram, eucalyptus, rosemary, and peppermint.22

Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial.  Essential oils blended with lavender (Lavandula officinalis), clary sage (Salvia sclarea) and marjoram (Origanum majorana).23

Menthol, the cooling natural product of peppermint, is widely used in medicinal preparations for the relief of acute and inflammatory pain in sports injuries, arthritis an Pain.24

Vitamins and supplements research in neuropathy.25

Alpha Lipoic Acid can help those suffering from diabetic neuropathy by positively influencing the metabolism of glucose.(1)  improves the flow of blood to the nerves.(2)  A dose of just 600 mg a day taken for 4 years improved symptoms and slowed down the progression of neuropathy.(3)

B-Vitamins can significantly relieve the symptoms of diabetic neuropathy.(4)(5). Vitamin B12 can extenuate nerve damage caused by neuropathy by activating a chemical signal, which helps nerves to regenerate.(6)  Combinations of Vitamin B12 and 6 (methylcobalmin, folic acid and pyridoxal) have been found to improve symptoms and maintain the health of nerves in the extremities.(7). Taken orally at 1500 mcg a day, research has found that it improves symptoms including numbness, pain and gait and it also proved more effective than notriptylene, a commonly prescribed antidepressant to treat neuropathic pain.(8)

Vitamin E alone can improve peripheral neuropathy symptoms and improve nerve function and health in those with type 2 diabetes.(9)

A deficiency in Vitamin D may be a risk factor in peripheral diabetic neuropathy. A deficiency is typically present in those with type 1 and 2 diabetes and is even more common in those suffering neuropathy symptoms.  One study published in 2008 was carried out on 51 patients and found that supplementing with Vitamin D reduced pain levels by up to 50%.(10)

Acetyl l-Carnitine might help increase insulin resistance, allow the cells to utilize glucose effectively and boost nerve regeneration.(11)  And helps reduce pain, improves the sensation of vibration in the limbs and helps nerves to regenerate. (11,12)

N-acetyl cysteine protects the nerves from oxidative stress and damage.(13)

Curcumin might be able to reduce pain signals caused by damaged nerves as well as preventing oxidative damage of the nerves.(14)

Resveratol combined with insulin reduced sensitivity to pains.(15)

Peppermint research on pain with cancer patients.26

Results from NCBI: “…This proof-of-concept study indicates that topical menthol has potential as a novel analgesic therapy for cancer treatment-related neuropathic pain. Improvements in patient-rated measures are supported by changes in objective measures of physical function and sensation. Further systematic evaluation of efficacy is required.”

A novel treatment of postherpetic neuralgia using peppermint oil.27

“…The authors believe this is the first evidence of peppermint oil (or menthol) having a strong analgesic effect on neuropathic pain.”

Nerve Injuries in Surgery and Nerve and/or Spinal Cord Complications.28

A nerve that is injured from compression (a common scenario with a disc herniation or bone spur) may not fully recover even after surgery that was designed to decompress the nerve. Under very careful and meticulous surgical manipulation, a nerve can still become damaged.  Pain can be from three causes:

  1. Instrumentation (Instrumentation can also cause nerve irritation or damage).
  2. Cervical Cord and Root Injuries (Some patients have such tight (stenotic) canals that the act of opening the canal to decompress the spinal cord can cause injury).
  3. Arachnoiditis (Arachnoiditisis inflammation of the membrane that surrounds the nerves in the canal).

There are three membranes, the dura mater, pia mater and the arachnoid that surround the spinal cord and nerves.

Dural Tear/Leak

During spine surgery, there exists the possibility that a small rent (or tear) of the dura will occur.  Most commonly, it occurs when attempting to remove material such as bone, ligament (ligamentum flavum), cyst, or disc material that is scarred or stuck to the dura. The incidence of dural tear increases with a history of prior surgery in the same area from scar formation.  Symptoms of a dural leak: most commonly, patients describe a positional headache in which standing aggravates and laying down improves and/or resolves the headache.  Other commonly reported symptoms include the following: nausea, dizziness, ringing in the ears and a feeling of malaise/fatigue.  Physical exam findings may note a swollen incision.

Treatment for dural leak

Further treatments, if a dural leak were to persist despite primary repair during surgery, include the following: blood patch, use of caffeine, and consideration of a ‘diverting drain’.  On rare occasions, re-operation must be considered.

Repair of the dura mater with processed collagen devices.29

From NCBI: “..These measured differences influenced device intraoperative handling and installation as well as the post-operative biological response, where differences in device resorption, cell penetration, vascularization, and collagen remodeling were observed.”

Basically it shows the importance of collagen relating with dura mater.  Similar to disk degeneration, basically the repair of the tissue is needed, and usually through surgery.

The effect of aroma inhalation method on stress responses of nursing students.30

In the experimental group, aromas were given using an aroma lamp, lavender, peppermint, rosemary and Clary-Sage. In the control group, the treatment was not administered.  As a result of administering aroma inhalation to nursing students, their physical symptoms decreased, their anxiety scores were low, and their perceived stress scores were low, showing that aroma inhalation could be a very effective stress management method.” Frankincense use against Cerebral Ischemic injury.31

Given the use of the Boswellia resin to treat all kinds of injuries as well as inflammatory conditions, the effects of its major anti-inflammatory constituent, IA mice following head trauma was examined.  Its anti-inflammatory effects were thus associated with improved neurobehavio, on ral and cognitive functions in a mouse model of traumatic brain injury (Pettigrew et al., 2008).

Effects of olfactory stimulation on the vigilance performance of individuals with brain injury 32

“..Observers with brain injury and control participants performed a vigilance task during which they received periodic whiffs of unscented air or air scented with peppermint. Under both fragrance conditions, controls reduced the frequency of commissive errors (false alarms) over the course of the vigil, an adaptive strategy given the low probability of signals employed (0.04). The false alarm rate of observers with brain injury increased precipitously toward the end of the vigil in the unscented air condition. However, exposure to the scent of peppermint rendered the false alarm scores of observers with brain injury similar to that of controls, a result which is consistent with evidence that olfactory stimulation activates brain areas vital for planning and judgment…”

Regarding NSAIDS for pain, I referenced an article a few years back on the effects of NSAIDS.33:

  1. Even at normal NSAID dosages, people with compromised kidney function can develop NSAID toxicity”.
  2. Adverse effects of NSAIDs cause 103,000 hospitalizations and 16,500 deaths per year in the United States.
  3. In patients with such a history, however, use of NSAIDs (aside from low-dose aspirin) was associated with more than 10-fold increase in heart failure.
  4. “You may as well wear a sign, ‘Please kill my kidneys’”(4, Rice University).

 

St. Jude’s Miracle Oil®.34

Regarding Neuropathy, or nerve pain, tingling, etc., I have received testimonials from those with pinched nerves, degenerated disk pain, muscle pain, and I remember almost two years ago Jiu-jitsu Master Carlos Machado and I both had a pinched nerve, mine due to training, his due to a chronic nerve pain he had for years.  The Miracle oil we used to apply on the direct area (shoulder, arm, etc.), and it did provide relief. We did it down the spine and what a difference!  Now I apply the oil directly on the spinal cord area of the back from the neck to the waist.  This way the oil seeps through the skin and can help relieve pain directly to the spinal cord.  A goal of ours would be to do more research, more trials in this area.  For medical references, are there any medical references to pain in the medical journals regarding the 9 oils we use in our Miracle oil product?  Unlike many products, we do not make claims of cures or medical treatments, as we note in our disclaimer below.  However, it is interesting to look at ncbi and pubmed references to pain.  We refer to medical journals on each of our 9 oils in St. Jude’s Miracle Oil®:

Wintergreen acts as an anti-inflammatory agent (1-4).

The medicinal properties of peppermint oil are analgesic, anti-septic, anti-inflammatory, and antimicrobial, among others (5).

Lavender has anti-inflammatory and analgesic properties (6), and pain relief assessment (7).

Eucalyptus Blue has anti-inflammatory and analgesic properties (8).

Clove bud has anti-infectious properties include: anti-viral, anti-bacterial, anti-fungal effects (9-10).

Geranium has shown temporary relief of neuralgia pain (11).

Clary Sage in pain relief on outpatients with primary dysmenorrhea (Painful menstration) (12).

Frankincense was used for symptomatic knee osteoarthritis (13)

Myrrh oil has anti-inflammatory and analgesic activity (14).

In closing on this article, I have to make another point that may be just as important as the research in here with nerve pain.  The CDC reported the major causes of death in the USA are from:

Heart disease: 611,105

Cancer: 584,881

Chronic lower respiratory diseases: 149,205

Accidents (unintentional injuries): 130,557

How many people think nutrition is related to nerve pain, or look at the correlation with surgeries? Let’s look at actual medical references.35:

  1. Skeletal diseases may be induced by malnutrition that involves certain nutrients, notably calcium, phosphorus, and vitamin D, but also iodine, copper, zinc, manganese, fluorine, silicon, vitamin A and perhaps vitamin C, as well as protein and energy. The number of these nutrients.
  2. Malnourished patients are more likely to have complications following total knee or hip replacement surgeries than morbidly obese patients, according to new research from researchers at the Perelman School of Medicine at the University of Pennsylvania. The findings are being presented at the American Academy of Orthopaedic Surgeons Annual Meeting. and their interactions is so large that dietary intervention in bone abnormalities is likely to be most effective if directed at consumption of a diet that is completely balanced for growth, maturity, old age, or stress.

I have many students and customers from the USA that keep purchasing the oil to help whether it smells good, sinuses, pain, or whatever they use it for.  We get orders from the UK, Australia too.  Even NBA players use our product. When I speak to the blind, many do not know a majority of blindness is preventable.  Did you know, according to the World Health Organization, that 80% of all visual impairment can be avoided or cured?

Read it: Reference: http://www.who.int/mediacentre/factsheets/fs282/en/

You can also read testimonials, before and after videos or pics on facebook for SJMO: https://www.facebook.com/groups/132501736829734/

Absorb and think,

Professor William Vandry

______________________________

As referenced on another website, Essential oils do not require FDA approval, however manufacturers are not allowed to claim that they prevent or treat illness. We do not make claims such as those, but oils in our product have been used separately in clinical trials in medical journals I have researched.

Disclaimer: The information presented on this site is not intended for diagnostic or treatment purposes. Please consult your own physician for medical advice or services. The information provided on this website is intended for informational purposes only, and should not be considered a replacement for the expert advice of a qualified health practitioner.  www.stjudesmiracleoil.com, www.austinbjj.com and www.williamvandry.com makes no representations as to accuracy, completeness, currentness, suitability, or validity of any information on this site and will not be liable for any errors, omissions, or delays in this information or any losses, injuries, or damages arising from its display or use. All information is provided on an as-is basis.

References

  1. (American Academy of Pain Medicine [AAPM], 2011)
  2. (Dickson, Head, Gitlow, & Osbahr, 2010, p. 1637). (Bennett, 1998, p. 104)
  3. (International Association for the Study of Pain [IASP], 2011)
  4. (falls, sports-related injuries, accidents, fractures, phantom limb pain, spinal cord compressions, complex regional pain syndrome, etc.)
  5. (Lindsay, Rodgers, Savath, & Hettinger, 2010, figure 1)

(The Northern California Chapter of the Neuropathy Association, 2008, p. 1-8).

(Peppin, 2011, p. 1-4)

  1. Aggarwal, B. B., Prasad, S., Reuter, S., Kannappan, R., Yadev, V. R., Park, B.,…Sung, B. (20011). Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: “Reverse pharmacology” and “Bedside to bench” approach. Curr Drug Targets, 12(11), 1595-1653. Retrieved from http://www.ncbi.nlm.nih.gov
  2. Hong, C. Z., & Shellock, F. G. (1991, February). Effects of a topically applied counterirritant (Eucalyptamint) on cutaneous blood flow and on skin and muscle temperatures. A
  3. (“Neuragen PN,” 2010, p. 2)
  4. (Maruyama et al., 2006, p. 4-7). Maruyama, N., Ishibashi, H., Hu, W., Morofuji, S., Inouye, S., Yamaguchi, H., & Abe, S. (2006, February). Suppression of carrageenan- and collagen II- induced inflammation in mice by geranium oil. Mediators of Inflammation, 2006(3), 1-7. doi: 10.1155/MI/2006/62537
  5. (Hur, Lee, Seong, & Lee, 2011, p. 2).4, Hur, M., Lee, M. S., Seong, K., & Lee, M. (2011). Aromatherapy massage on the abdomen for alleviating menstrual pain in high school girls: A preliminary controlled clinical study. Evidence-Based Complementary and Alternative Medicine, 1-3. doi: 10.1155/2012/187163 International Association for the Study of Pain. (2011). Neuropathic Pain. Retrieved from www.iasp-pain.org

 

  1. (Buckle, 1999, table 4). Buckle, J. (1999, September). Use of aromatherapy as a complimentary treatment for chronic pain. Alternative Therapies in Health and Medicine, 5(5), 1078-6791. Retrieved from Medline with Full Text, EBSCOhost
  2. Greenway, f, Frome & Engels, T. (2003). Temporary relief of postherpetic neuralgia pain with topical geranium oil. American J of Medicine, 115, 586-587.

 

  1. (Rose, 2006, p. 54-5).6. Rose, J. (2006, June/July). Aromatic solutions: Herbs & aromatherapy for pain. Massage and Bodywork, 52-6. Retrieved from http://naha.org
  2. (Shutes, n.d., p. 7-28). Shutes, J. (n.d.). Advanced Aromatherapy Certification Program. : Author. Terpines and their derivatives (White Paper). (n.d.). Retrieved from Virtual Centre for Innovative Learning Technologies at the University of Mauritius Website: http://www.vcampus.uom.ac.mu
  3. (Worwood, 1991, p. 39). Worwood, V. A. (1991). The complete book of essential oils & aromatherapy. Novato, CA: New World Library.
  4. McKay and Blumberg (2006, p.619) McKay, D. L., & Blumberg, J. B. (2006, August 20). A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytotherapy Research, 20(8), 619-33. doi: 10.1002/ptr.1936
  5. (Sharafi, Rasooli, Owila, Tachizadeh, & Astaneh, 2010, p. 147). Sharafi, S. M., Rasooli, I., Owila, P., Tachizadeh, M., & Astaneh, S. D. (2010, July 30). Protective effects of bioactive phytochemicals of Mentha piperita with multiple health potentials. Pharmacognosy Magazine, 6(23), 147-153. doi: 10.4103/0973-1296.66926
  6. Geranium (Bourbon) 100% Pure Therapeutic Grade Essential Oil- 10 ml. Edens Garden. Retrieved 5 May 2013 from http://www.amazon.com/Geranium-Bourbon-Therapeutic-GradeEssential/dp/B002RTAJDK  [5] Geranium macrorrhizum. Wikipedia. Retrieved 5 May 2013 from http://en.wikipedia.org/wiki/Geranium_macrorrhizum
  7. Rose geranium oil. WebMD, LLC. Retrieved 5 May 2013 from http://www.webmd.com/vitamins-supplements/ingredientmono-153-ROSE%20GERANIUM%20OIL.aspx
  8. Elmann A., Mordechay S., Rindner M., & Ravid U. (2010). Anti-neuroinflammatory effects of geranium oil in microglial cells. Journal of Functional Foods, 2: 17-22. Retrieved 3 May 2013 from http://www.sciencedirect.com/science/article/pii/S1756464609000796
  9. Pattnaik S., Subramanyam V. R., & Kole C. (1996). Antibacterial and antifungal activity of ten essential oils in vitro. Microbios, 86(349): 237-246. Retrieved 3 May 2013 from http://www.ncbi.nlm.nih.gov/pubmed/8893526
  10. Panahi Y. et al. (2012). Investigation of the effectiveness of Syzygium aromaticum, Lavandula angustifolia and Geranium robertianum essential oils in the treatment of acute external otitis: A comparative trial with ciprofloxacin. Journal of Microbiology, Immunology and Infection, pii: S1684-1182(12)00214-9. doi: 10.1016/j.jmii.2012.10.002. Retrieved 5 May 2013 from http://www.ncbi.nlm.nih.gov/pubmed/23274083
  11. (College of Nursing, The Catholic University of Korea, Korea, Taehan Kanho Hakhoe Chi. 2005 Feb;35(1):186-94.)
  12. (Department of Applied Cosmetology, Hungkuang University, Taichung, Taiwan.  J Obstet Gynaecol Res. 2012 May;38(5):817-22. doi: 10.1111/j.1447-0756.2011.01802.x. Epub  2012 Mar 22)
  13. Department of Pharmacology, Yale University School of Medicine, 333 Cedar St., New Haven, CT06520.

2013 Jun 29. pii: S0304-3959(13)00364-3. doi: 10.1016/j.pain.2013.06d other painful conditions.

  1. http://healthyfocus.org/10-proven-vitamins-and-supplements-for-neuropathy/

 

  1.  http://www.ncbi.nlm.nih.gov/pubmed/15512796 2.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176171/ 3.http://www.ncbi.nlm.nih.gov/pubmed/21775755 4. http://www.ncbi.nlm.nih.gov/pubmed/18473286 5.  http://www.ncbi.nlm.nih.gov/pubmed/15726875 6.  http://www.ncbi.nlm.nih.gov/pubmed/21128935 7.  http://www.ncbi.nlm.nih.gov/pubmed/23218892
  2. http://www.ncbi.nlm.nih.gov/pubmed/19212856 9.  http://www.ncbi.nlm.nih.gov/pubmed/9588854 10. http://archinte.jamanetwork.com/article.aspx?articleid=414131 11. http://www.ncbi.nlm.nih.gov/pubmed/18940920 12.  http://www.ncbi.nlm.nih.gov/pubmed/16461471 13. http://www.ncbi.nlm.nih.gov/pubmed/19840221 14.  http://www.ncbi.nlm.nih.gov/pubmed/22045654 15.  http://www.ncbi.nlm.nih.gov/pubmed/17177975

 

  1. Cancer treatment-related neuropathic pain: proof of concept study with menthol—a TRPM8 agonist.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519585/
  2. A novel treatment of postherpetic neuralgia using peppermint oil. Davies SJ1, Harding LM, Baranowski AP., http://www.ncbi.nlm.nih.gov/pubmed/12048423
  3. https://neckandback.com/pre-and-post-op/nerve-andor-spinal-cord-complications/
  4. Repair of the dura mater with processed collagen devices. Zerris VA1, James KS, Roberts JB, Bell E, Heilman CB. http://www.ncbi.nlm.nih.gov/pubmed/17465025
  5. The effect of aroma inhalation method on stress responses of nursing students, http://www.ncbi.nlm.nih.gov/pubmed/15314330
  6. Protective effects of incensole acetate on cerebral ischemic injury, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294134/
  7. Effects of olfactory stimulation on the vigilance performance of individuals with brain injury, http://www.ncbi.nlm.nih.gov/pubmed/9777477
  8. References:

 

  1. http://www.lef.org/protocols/appendix/otc_toxicity_01.htm (Whelton A et al 1991).
  2. An estimated 10-20% of NSAID patients experience dyspepsia, and NSAID-associated upper gastrointestinal adverse events are estimated to result in 103,000 hospitalizations and 16,500 deaths per year in the United States, and represent 43% of drug-related emergency visits. Many of these events are avoidable; a review of physician visits and prescriptions estimated that unnecessary prescriptions for NSAIDs were written in 42% of visits. Kearney, Pm; Baigent, C; Godwin, J; Halls, H; Emberson, Jr; Patrono, C (June 2006).
  3. “Do selective cyclo-oxygenase-2 inhibitors and traditional nonsteroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials”(Free full text). BMJ (Clinical research ed.)332 (7553): 1302–8. doi:10.1136/bmj.332.7553.1302.ISSN 0959-8138PMC 1473048PMID 167405583-Page, J; Henry, D (March 2000). “Consumption of NSAIDs and the development of congestive heart failure in elderly patients: an under recognized public health problem” (Free full text). Archives of internal medicine 160 (6): 777–84.doi:10.1001/archinte.160.6.777ISSN 0003-9926PMID 10737277.
  4. http://www.rice.edu/~jenky/sports/nsaid.html

 

  1. St. Jude’s Miracle Oil® References:

 

  1. Methyl salicylate 2-O-β-D-lactoside, a novel salicylic acid analogue, acts as an anti-inflammatory agent on microglia and astrocytes.Lan X, Liu R, Sun L, Zhang T, Du G.J Neuroinflammation. 2011 Aug 11;8:98. doi: 10.1186/1742-2094-8-98.
  2. A novel naturally occurring salicylic acid analogue acts as an anti-inflammatory agent by inhibiting nuclear factor-kappaB activity in RAW264.7 macrophages. Zhang T, Sun L, Liu R, Zhang D, Lan X, Huang C, Xin W, Wang C, Zhang D, Du G.Mol Pharm. 2012 Mar 5;9(3):671-7. doi: 10.1021/mp2003779. Epub 2012 Feb 15.
  3. Anti-inflammatory activity of methyl salicylate glycosides isolated from Gaultheria yunnanensis (Franch.) Rehder.Zhang D, Liu R, Sun L, Huang C, Wang C, Zhang DM, Zhang TT, Du GH.  Molecules. 2011 May 9;16(5):3875-84. doi: 10.3390/molecules16053875
  4. Evaluation of the new anti-inflammatory compound ethyl salicylate 2-O-β-d-glucoside and its possible mechanism of action.  Xin W, Huang C, Zhang X, Zhang G, Ma X, Sun L, Wang C, Zhang D, Zhang T, Du G.Int Immunopharmacol. 2012 Dec 4;15(2):303-308. doi:10.1016/j.intimp.2012.11.014.
  5. Mullally BH, James JA,CoulterWA,LindenGJ. The efficacy of a herbal-based toothpaste on the control of plaque and gingivitis. J Clin Periodontol. 1995;22(9):686–9.
  6. Hajhashemi, V., Ghannadi, A., & Sharif, B. (2003). Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of lavandula angustifolia mill. Journal of Ethnopharmacology, 89(1), 67-71.(Lavender)
  7. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial.  Ou MC, Hsu TF, Lai AC, Lin YT, Lin CC.  SourceDepartment of Applied Cosmetology,HungkuangUniversity,Taichung,Taiwan
  8. Phytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats.  Gbenou JD, Ahounou JF, Akakpo HB, Laleye A, Yayi E, Gbaguidi F, Baba-Moussa L, Darboux R, Dansou P, Moudachirou M, Kotchoni SO.  SourceLaboratoire de Pharmacognosie et des Huiles Essentielles, Faculté des Sciences de la Santé, Faculté des Sciences et Techniques, Université d’Abomey Calavi, 01 BP 918,Cotonou,Benin.
  9. Antifungal activity of the clove essential oil from aromaticum on Candida, Aspergillus and dermatophyte species Euge´ nia Pinto,1 Luı´s Vale-Silva,1 Carlos Cavaleiro2 and Lı´gia Salgueiro2
  10. Curr Med Chem. 2003 May;10(10):813-29.Antibacterial and antifungal properties of essential oils.  Kalemba D, Kunicka A.SourceInstitute of General Food Chemistry, TechnicalUniversity of Lodz,Poland.
  11. 20Greenway, f, Frome & Engels, T. (2003). Temporary relief of postherpetic neuralgia pain with topical geranium oil. American J of Medicine, 115, 586-587.
  12. Pain relief assessment by aromatic essential oil massage on outpatients with primary dysmenorrhea: a randomized, double-blind clinical trial.  Ou MC, Hsu TF, Lai AC, Lin YT, Lin CC.  SourceDepartment of Applied Cosmetology, HungkuangUniversity, Taichung, Taiwan.
  13. Rheumatology (Oxford). 2013 Jan 30. Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial.  Source Center for Rheumatic Diseases, Pune, School of Biomedical Sciences, Symbiosis International University, Pune, BJ Medical College, Pune, Department of Rheumatology, Nizam Institute of Medical Sciences, Hyderabad, Department of Medicine, All India Institute of Medical Sciences, Delhi, Interactive Research School for Health Affairs, Bharati Vidyapeeth Deemed University, Pune, SPARC Institute, Mumbai, Department of Medicine, KEM Hospital, Mumbai and Symbiosis International University, Pune, India
  14. Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha.  Source:JiangsuKey Laboratory for TCM Formulae Research,NanjingUniversityof   Chinese Medicine,Nanjing210046, PR China.

 

  1. Medical references nutrition disease

 

  1. http://cal.vet.upenn.edu/projects/saortho/chapter_58/58mast.htm
  2. http://www.uphs.upenn.edu/news/News_Releases/2015/03/malnutrition/